INCREASED POPULATIONS OF ENDOCRINE-CELLS IN CROHNS ILEITIS
INCREASED POPULATIONS OF ENDOCRINE-CELLS IN CROHNS ILEITIS
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DOI：
10.1007/bf00712758
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发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
POLAK, JM
中科院分区：
文献类型：
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作者：
BISHOP, AE;PIETROLETTI, R;POLAK, JM
以前在克罗恩病中描述过神经增生。为了确定肠道内分泌系统是否发生类似的改变，在典型的疾病病例中定量回肠上皮的内分泌细胞。在克罗恩病患者的回肠中，通过嗜铬粒蛋白的免疫染色可见内分泌细胞群增加。内分泌细胞数量的定量分析显示，与正常对照组（23.7±3.4）相比，克罗恩病组（35.0±3.8，每单位长度粘膜肌层细胞数平均值±SEM，P<0.05）和克罗恩病组（44.5± 5.5，P <0.01）的内分泌细胞数均显著增加。克罗恩病患者肠嗜铬细胞数虽有增加，但仅肠嗜铬细胞数明显增多（正常对照组10.5±2.3，克罗恩病组21.3± 4.4，P <0.05）。
Hyperplasia of nerves has been described previously in Crohn's disease. To determine whether similar alteration of the enteric endocrine system occurs, endocrine cells of the ileal epithelium were quantified in typical cases of the disease. In the ileum from patients with Crohn's disease, there was an increase in the endocrine cell population, as visualised by immunostaining of chromogranin. Quantification of endocrine cell numbers showed significant increases in both macroscopically uninvolved (i.e. histologically normal) (35.0±3.8, cells per unit length of muscularis mucosae mean ±SEM,P<0.05) and involved (44.5±5.5,P<0.01) Crohn's disease samples, compared with normal controls (23.7±3.4). Although individual types of endocrine cell showed slight increases in Crohn's samples, only the enterochromaffin cells in abnormal bowel showed a significantly greater population (normal controls 10.5±2.3; involved Crohn's 21.3±4.4,P<0.05).