Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity
Serum CRP levels are equally elevated in newly diagnosed type 2 diabetes and impaired glucose tolerance and related to adiponectin levels and insulin sensitivity
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DOI：
10.1016/j.diabres.2005.10.025
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发表时间：
2006-06-01
影响因子：
5.1
通讯作者：
Chen, Mingdao
中科院分区：
文献类型：
--
作者：
Yuan, Guoyue;Zhou, Libin;Chen, Mingdao
目的：测定正常对照组(NC)、糖耐量低减(IGT)和新诊断2型糖尿病(DM)患者血清超敏C反应蛋白(hs-CRP)和脂联素水平，评估胰岛素敏感指数(SI)和急性胰岛素反应(AIR)，进一步探讨IGT和新诊断2型糖尿病组hs-CRP与SI、AIR和AIR的可能相关性。结果：与正常对照组比较，糖耐量低减组和2型糖尿病组血清hs-CRP值均显著升高(P<0.001)，但后两组间差异无统计学意义。高敏C反应蛋白与高密度脂蛋白胆固醇、SI、脂联素水平呈负相关(p<；0.001~p<；0.001)，与收缩压、空腹血糖、体重指数、腰臀比、餐后2 h血糖、空腹胰岛素、餐后胰岛素呈正相关(p<；0.05~p<；0.001)。在一般多因素回归分析中，只有脂联素是血清hs-CRP值的显著独立决定因素(回归系数为-1.380；95%CI-2.062~0.698，p<；0.001)，而甘油三酯、SI、hs-CRP、FINS、2hPG和腰臀比是血清脂联素浓度的显著独立决定因素(p<；0.05~p<；0.001)。结论：血清hs-CRP值升高可能参与胰岛素抵抗综合征和2型糖尿病的发生发展。这种升高伴随着脂联素的相反变化。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Aims: To measure the serum highly sensitive C-reactive protein (hs-CRP) and adiponectin levels, assess insulin sensitivity index (SI) and acute insulin response (AIR) in normal control (NC) subjects, patients with impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes mellitus (DM), and further explore the possible correlation between hs-CRP and SI, AIR and adiponectin in IGT and newly diagnosed type 2 DM groups.Methods: Age and sex matched 28 normal subjects, 31 patients with IGT, and 31 patients with newly diagnosed type 2 DM were included in the study. SI and AIR were assessed by the reduced sample number of Bergman's minimal model method with intravenous glucose tolerance test in subjects of each group.Results: Compared with NC group, serum hs-CRP was significantly increased in IGT and type 2 DM groups (p < 0.001), although there was no significant difference between the latter groups. Hs-CRP was negatively correlated with high density lipoprotein cholesterol (HDL-C), SI and adiponectin levels (p < 0.05 to p < 0.001), and positively correlated with systolic blood pressure (SBP), fasting plasma glucose (FPG), BMI, waist-to-hip ratio (WHR), postprandial 2h plasma glucose (2hPG), fasting serum insulin (FINS) and postprandial serum insulin (PSI) in IGT and newly diagnosed type 2 DM groups (p < 0.05 to p < 0.001). In general multivariate regression, only adiponectin was the significantly independent determinant for serum hs-CRP (regression coefficient -1.380; 95% CI-2.062 to 0.698, p < 0.001); meanwhile, TG, SI, hs-CRP, FINS, 2hPG and WHR were significantly independent determinants for serum adiponectin concentration (p < 0.05 to p < 0.001).Conclusions: Elevated serum hs-CRP may play a role in the development of insulin resistance syndrome and type 2 diabetes. This elevation is accompanied by the opposite changes of adiponectin. (c) 2005 Elsevier Ireland Ltd. All rights reserved.