Hepatitis C virus co‐infection is a negative prognostic factor for clinical evolution in human immunodeficiency virus‐positive patients
Hepatitis C virus co‐infection is a negative prognostic factor for clinical evolution in human immunodeficiency virus‐positive patients
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丙型肝炎病毒合并感染是人类免疫缺陷病毒阳性患者临床演变的负面预后因素
DOI：
10.1046/j.1365-2893.2000.00227.x
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发表时间：
2000
影响因子：
2.5
通讯作者：
H. Portier
中科院分区：
文献类型：
--
作者：
L. Piroth;M. Grappin;L. Cuzin;Y. Mouton;O. Bouchard;F. Raf;D. Rey;D. Peyramond;F. Gourdon;C. Drobacheff;Marie;F. Lucht;J. Besnier;L. Bernard;P. Chavanet;H. Portier
A longitudinal study of human immunodeficiency virus (HIV)‐infected individuals followed‐up in 13 centres was performed to assess the influence of hepatitis C virus (HCV) on the clinical and immunological evolution of HIV‐infected patients. Eight‐hundred and twelve HIV‐infected patients with known HIV acquisition date, 89 co‐infected with HCV, were included in the cohort. Clinical progression was defined as: 30% decrease of Karnofsky’s index; and/or 20% body weight loss; and/or acquired immune deficiency syndrome (AIDS)‐defining illness; and/or death (except by accident, suicide, or overdose). Immunological progression was defined as a decrease of initial CD4 count to below 200 mm–3. If immunological progression was not statistically different between groups (P=0.25), clinical progression was significantly faster in HCV–HIV co‐infected patients in univariate (P=0.02) and multivariable survival analysis (hazard ratio=1.63, P=0.03). This argues for active management of hepatitis C chronic infection among HCV–HIV co‐infected patients.
多次输血血友病患者丙型肝炎病毒感染的自然史：与人类免疫缺陷病毒共感染的影响。
DOI：
--
发表时间：
1993
期刊：
Journal of acquired immune deficiency syndromes
影响因子：
--
作者：
Eyster,ME;Diamondstone,LS;Lien,JM;Ehmann,WC;Quan,S;Goedert,JJ
通讯作者：
Goedert,JJ