SEOM Clinical guidelines for the treatment of advanced colorectal cancer 2013
SEOM Clinical guidelines for the treatment of advanced colorectal cancer 2013
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DOI：
10.1007/s12094-013-1082-5
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发表时间：
2013-12-01
影响因子：
3.4
通讯作者：
Garcia-Carbonero, R.
中科院分区：
文献类型：
--
作者：
Casado-Saenz, E.;Feliu, J.;Garcia-Carbonero, R.
结直肠癌（CRC）是西方国家最常见的恶性肿瘤。尽管努力实施早期发现和治疗的筛查方案，但仍有一半的患者存在或最终将发展为远处转移。晚期结直肠癌的治疗应在一个经验丰富的多学科团队中进行讨论，以充分选择最合适的全身治疗方案，以及在指诊时将其与外科手术相结合的最佳方式。疾病的定位和范围、原发和转移性疾病的可切除性、肿瘤生物学和动力学、临床症状、个人偏好以及患者耐受高强度化疗或广泛手术的能力是正确设计定制治疗方案的关键因素。当前稿件的目的是提供关于晚期结直肠癌治疗方案的综合实用指南。
Colorectal cancer (CRC) is the most common malignant tumor in Western countries. Despite efforts made to implement screening programmes for early detection and treatment, still half of the patients present or will eventually develop distant metastasis. Management of advanced CRC should be discussed within an experienced multidisciplinary team, to adequately select the most appropriate systemic therapeutic option, as well as the optimal way to integrate it with surgical procedures when indicated. Disease localization and extent, resectability of primary and metastatic disease, tumor biology and dynamics, clinical symptoms, personal preferences and patient's ability to tolerate intensive chemotherapy or extensive surgical procedures are the key factors to properly design a customized treatment plan. The aim of the current manuscript is to provide synthetic practical guidelines regarding therapeutic options for advanced CRC.