Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor
Facile Preparation of N-Alkyl-2-pyrrolidones in a Continuous-Flow Microreactor
复制标题
在连续流微反应器中轻松制备 N-烷基-2-吡咯烷酮
DOI：
10.1021/acs.oprd.7b00392
复制
发表时间：
2018
影响因子：
3.4
通讯作者：
Chen Guangwen
中科院分区：
文献类型：
--
作者：
Zhou Feng;Zhang Boyu;Liu Hongchen;Wen Zhenghui;Wang Kejun;Chen Guangwen
N-烷基-2-吡咯烷酮广泛应用于石油化工、农药化工、电子材料等领域，作为溶剂或反应介质的独特优势使其显得尤为重要。利用连续流动微反应器以高度可控和安全的方式制备N-甲基-2-吡咯烷酮（NMP）和N-乙基-2-吡咯烷酮（NEP），因此，它的使用提高了该过程的效率。考察了反应温度、停留时间、胺与γ-丁内酯（GBL）摩尔比、GBL浓度、水含量和H3 BO 3催化剂对NMP/NEP合成的影响。在微型反应器中，GBL转化为NMP和NEP，在优化条件下，NMP和NEP的收率分别达到94.7%和93.9%。在此基础上，建立了基于反应机理的动力学模型，为NMP/NEP合成工艺的设计和优化提供了指导。
N-Alkyl-2-pyrrolidones have been widely used in the petrochemical industry, the agricultural chemical industry, electronic materials, etc. The distinct advantages of using N-alkyl-2-pyrrolidones as solvents or reaction media make them particularly important. A continuous-flow microreactor was exploited for the preparation of N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP) in a highly controlled and safe manner; thus, its use improved the efficiency of the process. Various conditions (temperature, residence time, molar ratio of amine to γ-butyrolactone (GBL), GBL concentration, water content, and presence of H3BO3 catalyst) were investigated to improve the synthesis of NMP/NEP. A microreactor was employed for the conversion of GBL to NMP and NEP, and the yields reached 94.7% for NMP and 93.9% for NEP under the optimized conditions. Furthermore, a kinetic model based on the reaction mechanism was proposed to guide the design and optimization of the synthesis of NMP/NEP.