REACTIVITY TO MYELIN ANTIGENS IN MULTIPLE-SCLEROSIS - PERIPHERAL-BLOOD LYMPHOCYTES RESPOND PREDOMINANTLY TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN
REACTIVITY TO MYELIN ANTIGENS IN MULTIPLE-SCLEROSIS - PERIPHERAL-BLOOD LYMPHOCYTES RESPOND PREDOMINANTLY TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN
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DOI：
10.1172/jci116875
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发表时间：
1993-12-01
影响因子：
15.9
通讯作者：
BENNUN, A
中科院分区：
文献类型：
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作者：
DEROSBO, NK;MILO, R;BENNUN, A
尽管T细胞对主要的髓鞘蛋白（髓鞘碱性蛋白[MBP]和蛋白脂质蛋白[PLP]）的反应在多发性硬化症（MS）的病程中可能很重要，但细胞介导的对其他髓鞘抗原，特别是含量较少的髓鞘抗原，如髓鞘相关糖蛋白（MAG）和中枢神经系统特异性髓鞘少突胶质细胞糖蛋白（MOG）的自身免疫反应，也可能在疾病的起始或进展中起重要作用。本研究使用高度纯化的髓鞘抗原来评估MS患者对MOG的细胞介导免疫反应，并结合对其他髓鞘抗原（MBP、PLP和MAG）的反应性进行研究。MS患者外周血淋巴细胞增殖反应发生率最高的是对MOG，在检测的24名患者中有12名有反应，其中8名仅对MOG有反应。相比之下，在检测的16名对照个体中只有1名对MOG呈阳性反应。MS患者和对照个体对MBP、PLP和MAG的反应发生率没有很大差异。MS中对MOG的主要T细胞反应性表明，细胞介导的对该抗原的免疫反应在MS的发病机制中起重要作用。
Although T cell responses to the quantitatively major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), are likely to be of importance in the course of multiple sclerosis (MS), cell-mediated autoimmune responses to other myelin antigens, in particular quantitatively minor myelin antigens, such as myelin-associated glycoprotein (MAG) and the central nervous system-specific myelin oligodendrocyte glycoprotein (MOG), could also play a prevalent role in disease initiation or progression. Highly purified myelin antigens were used in this study to assess cell-mediated immune response to MOG in MS patients, in the context of the reactivity to other myelin antigens, MBP, PLP, and MAG. The greatest incidence of proliferative response by MS peripheral blood lymphocytes was to MOG, as 12 of 24 patients tested reacted and, of these, 8 reacted to MOG exclusively. In contrast, only 1 control individual of 16 tested reacted positively to MOG. The incidence of responses to MBP, PLP, and MAG did not differ greatly between MS patients and control individuals. A predominant T cell reactivity to MOG in MS suggests an important role for cell-mediated immune response to this antigen in the pathogenesis of MS.