Neuroimaging in drug abuse.
Neuroimaging in drug abuse.
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DOI：
10.1007/s11920-003-0068-3
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发表时间：
2003-10-01
影响因子：
6.7
通讯作者：
Volkow, Nora D
中科院分区：
文献类型：
--
作者：
Lindsey, Kimberly P;Gatley, S John;Volkow, Nora D
神经成像技术，包括正电子发射断层扫描（PET），是研究成瘾的理想选择。随着时间的推移，这些微创模式提供了关于急性和长期药物引起的大脑结构和功能变化的信息。在给药过程中，可以观察到人类和动物大脑的变化。PET神经成像可以精确量化和可视化药物及其在体内的运动速率。此外，影像学显示戒断吸毒者的功能恢复和神经元标记物的再现。越来越多的证据表明，PET可能用于识别易上瘾的个体。最后，候选药物治疗药物成瘾可以批判性地评估。这些独特的资产清楚地指出了这些策略在成瘾研究中的应用。
Neuroimaging techniques, including positron emission tomography (PET), are ideally suited for studies of addiction. These minimally invasive modalities yield information about acute and long-term drug-induced structural and functional changes in the brain over time. Changes can be observed in the brains of human and animal subjects during drug self-administration. Neuroimaging with PET allows precise quantification and visualization of the drug and its rates of movement in the body. In addition, imaging reveals recovery of function and reappearance of neuronal markers in abstinent drug users. Evidence that suggests that PET may have use in identifying individuals predisposed to become addicted is emerging. Finally, candidate pharmacotherapies for drug addiction can be critically evaluated. These unique assets clearly point to the use of these strategies for addiction studies.