The HUNT study: A population-based cohort for genetic research.
The HUNT study: A population-based cohort for genetic research.
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DOI：
10.1016/j.xgen.2022.100193
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发表时间：
2022-10-12
期刊：
影响因子：
--
通讯作者：
Willer, Cristen J.
中科院分区：
文献类型：
--
作者：
Brumpton, Ben M.;Graham, Sarah;Surakka, Ida;Skogholt, Anne Heidi;Loset, Mari;Fritsche, Lars G.;Wolford, Brooke;Zhou, Wei;Nielsen, Jonas Bille;Holmen, Oddgeir L.;Gabrielsen, Maiken E.;Thomas, Laurent;Bhatta, Laxmi;Rasheed, Humaira;Zhang, He;Kang, Hyun Min;Hornsby, Whitney;Moksnes, Marta Riise;Coward, Eivind;Melbye, Mads;Giskeodegard, Guro F.;Fenstad, Jorn;Krokstad, Steinar;Naess, Marit;Langhammer, Arnulf;Boehnke, Michael;Abecasis, Goncalo R.;Asvold, Bjorn Olav;Hveem, Kristian;Willer, Cristen J.
特伦德拉格健康研究（Hunt）是一项基于人口的队列研究，从1984年开始在挪威特伦德拉格县分四波招募了229，000人。这些人中大约有88，000人拥有来自阵列基因分型的遗传数据。HUNT参与者在四个以社区为基础的招募波中招募，并提供有关健康相关行为，自我报告诊断，疾病家族史的信息，并接受体检。通过挪威个人身份证号码建立的联系将来自医生就诊和国家健康登记册（包括死亡、癌症和处方登记册）的数字化保健信息整合在一起。HUNT参与者的全基因组关联研究为心血管、代谢、骨质疏松和肝脏相关疾病等的机制提供了见解。该队列的独特特征有利于研究，包括在积极和受过良好教育的人群中进行近40年的纵向随访，家庭数据，全面的表型分析，以及广泛的DNA，RNA，尿液，粪便，血浆和血清样本。Trøndelag健康研究（HUNT）是一项大型的、基于基因分型人群的队列研究。通过近40年的随访，可以获得全面的健康相关信息。国家个人身份证号码整合了数字化的医疗保健信息。HUNT参与者的GWAS为疾病机制提供了见解。介绍了Trøndelag健康研究（HUNT）的遗传队列概况，这是一项来自挪威Trøndelag县的大型基因型人群队列研究。他们描述了异常丰富的特征，使其成为遗传研究的优秀群体。这些措施包括自1984年以来的重复调查数据，生物材料的广泛可用性，以及与患者电子健康记录和人口登记联系的可能性。他们展示了HUNT如何帮助理解人类特征和疾病的遗传贡献，并描述了未来的研究机会。
The Trøndelag Health Study (HUNT) is a population-based cohort of ∼229,000 individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway. Approximately 88,000 of these individuals have available genetic data from array genotyping. HUNT participants were recruited during four community-based recruitment waves and provided information on health-related behaviors, self-reported diagnoses, family history of disease, and underwent physical examinations. Linkage via the Norwegian personal identification number integrates digitized health care information from doctor visits and national health registries including death, cancer and prescription registries. Genome-wide association studies of HUNT participants have provided insights into the mechanism of cardiovascular, metabolic, osteoporotic, and liver-related diseases, among others. Unique features of this cohort that facilitate research include nearly 40 years of longitudinal follow-up in a motivated and well-educated population, family data, comprehensive phenotyping, and broad availability of DNA, RNA, urine, fecal, plasma, and serum samples. The Trøndelag Health Study (HUNT) is a large, genotyped population-based cohort Comprehensive health-related information is available with nearly 40 years follow-up A national personal identification number integrates digitized health care information GWASs of HUNT participants have provided insights into mechanism of disease Brumpton et al. present the genetic cohort profile of the Trøndelag Health Study (HUNT), a large, genotyped population-based cohort from Trøndelag County, Norway. They describe the extraordinarily rich features that make it an excellent cohort for genetic research. These include repeated survey data since 1984, broad availability of biological material, and the possibility to link with patient electronic health records and population registries. They show how HUNT has aided in understanding the genetic contribution to human traits and disease and describe future opportunities for research.
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影响因子：
14.8
作者：
通讯作者：
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影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
2.1
作者：
Feng, Shuang;Pistis, Giorgio;Zhang, He;Zawistowski, Matthew;Mulas, Antonella;Zoledziewska, Magdalena;Holmen, Oddgeir L.;Busonero, Fabio;Sanna, Serena;Hveem, Kristian;Willer, Cristen;Cucca, Francesco;Liu, Dajiang J.;Abecasis, Goncalo R.
通讯作者：
Abecasis, Goncalo R.
DOI：
10.1038/gim.2013.73
发表时间：
2013-07
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ