2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated depression of rat testicular heme synthesis and microsomal cytochrome P-450.
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated depression of rat testicular heme synthesis and microsomal cytochrome P-450.
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2,3,7,8-四氯二苯并-p-二恶英介导的大鼠睾丸血红素合成和微粒体细胞色素 P-450 的抑制。
DOI：
10.1016/0006-2952(82)90592-5
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发表时间：
1982
影响因子：
5.8
通讯作者：
Piper,WN
中科院分区：
文献类型：
--
作者：
Tofilon,PJ;Piper,WN
接触2，3，7，8-四氯二苯并-对二恶英(TCDD)会导致多毛症、脱发和氯化，这些症状表明内分泌功能可能发生改变。因此，我们研究了TCDD对大鼠睾丸细胞色素P-450含量的影响。单次口服TCDD(25μg/kg)48小时后，睾丸微粒体细胞色素P-450水平降低约24%。微粒体细胞色素P-450在治疗后4天继续下降到对照水平的62%，并在治疗后7天保持在大致相同的水平。给予TCDD后，睾丸微粒体中的血红素含量呈现出类似的规律。睾丸δ-氨基乙酰丙酸(ALA)合酶无明显变化。TCDD给药后24小时，[14C]ALA掺入微粒体血红素的量降至对照组的约36%。在7天的实验期内，睾丸重量没有变化。这些数据表明，TCDD通过抑制睾丸血红素的合成来抑制大鼠睾丸细胞色素P-450的水平。
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces hirsutism, alopecia, and chlorance, symptoms that suggest a possible alteration of endocrine function. Therefore, the effects of TCDD on rat testicular cytochrome P-450 content were investigated. Forty-eight hours after a single, oral dose of TCDD (25 μg/kg) testicular microsomal cytochrome P-450 levels were depressed by approximately 24%. Microsomal cytochrome P-450 continued to decrease to 62% of control levels at 4 days and remained at approximately the same levels 7 days following treatment. Testicular microsomal heme content exhibited a similar pattern after administration of TCDD. No alterations in testicular δ-aminolevulinic acid (ALA) synthase were detected. The incorporation of [14C]ALA into microsomal heme was decreased to approximately 36% of control values at 24 hr after TCDD administration. Testicular weights were not altered during the 7-day experimental period. These data suggest that TCDD depresses cytochrome P-450 levels in the rat testis through an inhibition of the synthesis of testicular heme.
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