Ocean Acidification Amplifies the Olfactory Response to 2-Phenylethylamine: Altered Cue Reception as a Mechanistic Pathway?
Ocean Acidification Amplifies the Olfactory Response to 2-Phenylethylamine: Altered Cue Reception as a Mechanistic Pathway?
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DOI：
10.1007/s10886-021-01276-9
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发表时间：
2021-11
影响因子：
2.3
通讯作者：
Hardege JD
中科院分区：
文献类型：
--
作者：
Schirrmacher P;Roggatz CC;Benoit DM;Hardege JD
随着二氧化碳 (CO2) 水平急剧上升，气候变化威胁着海洋环境。由于海洋中二氧化碳浓度不断增加，pH 值预计到本世纪末将下降 0.4 个单位。迫切需要了解海洋酸化对化学生态过程的影响。迄今为止，海洋 pH 值下降影响化学通讯的程度和机制尚不清楚。将行为分析与计算化学相结合，我们探索了寄居蟹（Pagurus bernhardus）捕食者相关线索 2-苯乙胺 (PEA) 在当前和本世纪末海洋 pH 值中的功能。寄居蟹生活在潮间带环境中，除了与气候变化相关的海洋酸化之外，还面临着当前栖息地 pH 值的大幅波动。我们证明，哺乳动物和海七鳃鳗的饮食捕食者线索 PEA 对寄居蟹具有引诱剂，该线索的效力随着 pH 值的降低而增加。为了解释这种效力的增加，我们将 PEA 构象和电荷相关特性的变化评估为一种潜在的机制途径。利用核磁共振波谱验证的量子化学计算，我们表征了水中 PEA 的不同质子化状态。我们使用 PEA 的可能模型受体（人 TAAR1）展示了 PEA 的质子化如何影响受体-配体结合。通过调查 pH 依赖性影响 PEA 嗅觉和相应行为反应的潜在机制，我们的研究增进了对海洋酸化如何干扰嗅觉，从而可能影响海洋生态系统中重要的生态相互作用的理解。在线版本包含可在 10.1007/s10886-021-01276-9 获取的补充材料。
With carbon dioxide (CO2) levels rising dramatically, climate change threatens marine environments. Due to increasing CO2 concentrations in the ocean, pH levels are expected to drop by 0.4 units by the end of the century. There is an urgent need to understand the impact of ocean acidification on chemical-ecological processes. To date, the extent and mechanisms by which the decreasing ocean pH influences chemical communication are unclear. Combining behaviour assays with computational chemistry, we explore the function of the predator related cue 2-phenylethylamine (PEA) for hermit crabs (Pagurus bernhardus) in current and end-of-the-century oceanic pH. Living in intertidal environments, hermit crabs face large pH fluctuations in their current habitat in addition to climate-change related ocean acidification. We demonstrate that the dietary predator cue PEA for mammals and sea lampreys is an attractant for hermit crabs, with the potency of the cue increasing with decreasing pH levels. In order to explain this increased potency, we assess changes to PEA’s conformational and charge-related properties as one potential mechanistic pathway. Using quantum chemical calculations validated by NMR spectroscopy, we characterise the different protonation states of PEA in water. We show how protonation of PEA could affect receptor-ligand binding, using a possible model receptor for PEA (human TAAR1). Investigating potential mechanisms of pH-dependent effects on olfactory perception of PEA and the respective behavioural response, our study advances the understanding of how ocean acidification interferes with the sense of smell and thereby might impact essential ecological interactions in marine ecosystems. The online version contains supplementary material available at 10.1007/s10886-021-01276-9.
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DOI：
10.1016/j.jembe.2011.11.013
发表时间：
2012-01-31
影响因子：
2
作者：
de la Haye, Kate L.;Spicer, John I.;Briffa, Mark
通讯作者：
Briffa, Mark
影响因子：
2.9
作者：
DSOUZA, UM;STRANGE, PG
通讯作者：
STRANGE, PG
影响因子：
2.6
作者：
Di Rocco, Richard T.;Imre, Istvan;Brown, Grant E.
通讯作者：
Brown, Grant E.
影响因子：
2.1
作者：
Cohen, JH;Forward, RB
通讯作者：
Forward, RB
影响因子：
5.6
作者：
Andujar, Sebastian A.;Tosso, Rodrigo D.;Enriz, Ricardo D.
通讯作者：
Enriz, Ricardo D.