An Efficient Method for the Synthesis of α-Hydroxyalkyl Aryl Ketones
An Efficient Method for the Synthesis of α-Hydroxyalkyl Aryl Ketones
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DOI：
10.1055/s-0028-1083149
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发表时间：
2008-10-17
影响因子：
2.6
通讯作者：
Huang, Guosheng
中科院分区：
文献类型：
--
作者：
Chen, Chengqun;Feng, Xinghua;Huang, Guosheng
在催化量的碘苯存在下，烷基芳基酮暴露于氧酮(R)/三氟乙酸酐，可获得高产的α -羟基烷基芳基酮。该方法为在酮类中安装α -羟基基团提供了一条经济有效的途径，在天然产物合成中构建α -羟基酮亚基方面具有广泛的应用前景。
Exposure of alkyl aryl ketones to Oxone (R)/trifluoroacetic anhydride in the presence of a catalytic amount of iodobenzene affords alpha-hydroxyalkyl aryl ketones in good yield. This method provides an effective and economical entry for the installation of alpha-hydroxy moieties into ketones and should find wide application in the construction of the a-hydroxy ketone subunit in natural product synthesis.