Thoughts, behaviour, and brain dynamics during navigation in the real world
Thoughts, behaviour, and brain dynamics during navigation in the real world
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DOI：
10.1016/j.neuroimage.2006.01.037
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发表时间：
2006-07-15
期刊：
影响因子：
5.7
通讯作者：
Maguire, Eleanor A.
中科院分区：
文献类型：
--
作者：
Spiers, Hugo J.;Maguire, Eleanor A.
人类大脑如何让我们与不断变化的世界互动并在其中导航？虽然使用功能性脑成像的对照实验可以提供对相对简单的刺激的神经元反应的有见地的快照，但它们不能希望反映大脑在真实的世界中所面临的挑战。然而，试图研究支持日常生活的大脑机制是一个巨大的挑战。通过结合功能性神经成像，一个准确的互动虚拟模拟繁华的伦敦（英国），和一种新颖的手段“阅读”参与者的想法，而他们在城市周围移动，我们确定了在线神经相关支撑导航在这个现实世界的背景下。揭示了神经动力学的复杂编排，包括局灶性和分布式，短暂和持续的大脑活动。我们的研究结果提供了新的见解，个别脑区的具体作用，特别是海马，压后和额叶皮质，以及提供有关功能专业化如何在动态脑系统中运作的线索。(c)2006年爱思唯尔公司All rights reserved.
How does the human brain allow us to interact with and navigate through a constantly changing world? Whilst controlled experiments using functional brain imaging can give insightful snapshots of neuronal responses to relatively simplified stimuli, they cannot hope to mirror the challenges faced by the brain in the real world. However, trying to study the brain mechanisms supporting daily living represents a huge challenge. By combining functional neuroimaging, an accurate interactive virtual simulation of a bustling central London (UK), and a novel means of 'reading' participants' thoughts whilst they moved around the city, we ascertained the online neural correlates underpinning navigation in this real-world context. A complex choreography of neural dynamics was revealed comprising focal and distributed, transient and sustained brain activity. Our results provide new insights into the specific roles of individual brain areas, in particular the hippocampus, retrosplenial, and frontal cortices, as well as offering clues about how functional specialisations operate within dynamic brain systems. (c) 2006 Elsevier Inc. All rights reserved.