Fabrication of calcium phosphate films for coating on titanium substrates heated up to 773 K by RF magnetron sputtering and their evaluations
Fabrication of calcium phosphate films for coating on titanium substrates heated up to 773 K by RF magnetron sputtering and their evaluations
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DOI：
10.1088/1748-6041/2/3/s14
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发表时间：
2007-09-01
影响因子：
4
通讯作者：
Katsube, Tomoyuki
中科院分区：
文献类型：
--
作者：
Ueda, Kyosuke;Narushima, Takayuki;Katsube, Tomoyuki
采用射频磁控溅射技术在加热至773 K的钛基上制备了磷酸钙薄膜。研究了磷酸钙薄膜的沉积速率、相和择优取向。采用Hanks溶液和PBS（-）对膜进行浸渍试验，并研究磷酸钙膜包覆后样品的表面反应。对浸渍试验前后涂层与钛基体的结合强度进行了评价；浸渍试验后粘结强度下降。在钛板上包被磷酸钙膜的SaOS-2细胞通过培养试验检测碱性磷酸酶（ALP）活性。磷酸钙包被可提高培养3、7 d的SaOS- 2细胞ALP活性。将钛圆柱体涂以无定形磷酸钙薄膜，植入比格犬下颌骨。与未涂覆钛柱相比，在植入后8至12周，涂覆钛柱的骨与种植体接触程度有所增加。
Calcium phosphate films were fabricated on titanium substrates heated up to 773 K using radiofrequency (RF) magnetron sputtering. The deposition rate, phase and preferred orientation of the calcium phosphate films were studied. Immersion tests for the films were conducted using Hanks' solution and PBS(-), and the surface reactions on the specimens coated with the calcium phosphate films were investigated. The bonding strength between the coating films and the titanium substrates before and after the immersion tests was evaluated; the bonding strength decreased after the immersion tests. The alkaline phosphatase ( ALP) activity of SaOS-2 cells on a titanium plate coated with a calcium phosphate film was examined by conducting a culture test. Calcium phosphate coating increased the ALP activity of SaOS- 2 cells cultured for 3 and 7 days. Titanium cylinders were coated with an amorphous calcium phosphate film and implanted into the mandibles of beagle dogs. An increase in the extent of bone-implant contact for the coated titanium cylinders was confirmed 8 to 12 weeks after implantation and compared with the case for uncoated titanium cylinders.