Composites for Delivery of Therapeutics: Combining Melt Electrospun Scaffolds with Loaded Electrosprayed Microparticles
Composites for Delivery of Therapeutics: Combining Melt Electrospun Scaffolds with Loaded Electrosprayed Microparticles
复制标题
DOI：
10.1002/mabi.201300276
复制
发表时间：
2014-02-01
影响因子：
4.6
通讯作者：
Dargaville, Tim R.
中科院分区：
文献类型：
--
作者：
Bock, Nathalie;Woodruff, Maria A.;Dargaville, Tim R.
报道了一种新的策略，以生产可生物降解的微纤维支架与高密度的微粒封装的模型蛋白质层。在高度多孔的熔融电纺支架上的直接电喷涂在整个架构中提供了可再现的支架涂层。蛋白质的突释由于微粒在支架表面上的固定而显著减少，并且释放机制依赖于蛋白质-聚合物相互作用。复合支架与前体成骨细胞接触培养长达18天，具有积极的生物学效应。这里提出的技术实现的支架设计赞同这些新的复合支架作为有前途的模板生长因子的交付。
A novel strategy is reported to produce biodegradable microfiber-scaffolds layered with high densities of microparticles encapsulating a model protein. Direct electrospraying on highly porous melt electrospun scaffolds provides a reproducible scaffold coating throughout the entire architecture. The burst release of protein is significantly reduced due to the immobilization of microparticles on the surface of the scaffold and release mechanisms are dependent on protein-polymer interactions. The composite scaffolds have a positive biological effect in contact with precursor osteoblast cells up to 18 days in culture. The scaffold design achieved with the techniques presented here endorses these new composite scaffolds as promising templates for growth factor delivery.