Forensic Mass Spectrometry
Forensic Mass Spectrometry
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DOI：
10.1146/annurev-anchem-071114-040335
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Jackson, Glen P.
中科院分区：
文献类型：
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作者：
Hoffmann, William D.;Jackson, Glen P.
法医质谱学的发展往往是跟随而不是引领其他学科的发展。具有独立于法医应用而产生的法医潜力的技术的示例包括环境电离、成像质谱、同位素比质谱、便携式质谱仪和联用色谱-质谱仪器，仅举几例。法医科学有可能从其他方式资助的发展中受益匪浅，只要基础设施和人员存在，可以采用，验证和实施新技术到案件工作中。也许法医学处于前沿的一个独特领域是化学计量学和确定用于评估证据权重的似然比。这种统计技术已广泛用于可燃液体残留物分析和同位素比分析。本综述试图捕捉法医质谱发展领域的趋势、动力和可能的影响，但需要注意的是，除非以下情况，否则本研究不可能对法医界产生任何真实的影响：（a）将研制的仪器变成坚固的黑盒子，分别为正片和负片亮起红灯和绿色灯，或者（B）劳动力中有博士毕业生，他们可以帮助采用这些复杂的技术。
Developments in forensic mass spectrometry tend to follow, rather than lead, the developments in other disciplines. Examples of techniques having forensic potential born independently of forensic applications include ambient ionization, imaging mass spectrometry, isotope ratio mass spectrometry, portable mass spectrometers, and hyphenated chromatography-mass spectrometry instruments, to name a few. Forensic science has the potential to benefit enormously from developments that are funded by other means, if only the infrastructure and personnel existed to adopt, validate, and implement the new technologies into casework. Perhaps one unique area in which forensic science is at the cutting edge is in the area of chemometrics and the determination of likelihood ratios for the evaluation of the weight of evidence. Such statistical techniques have been developed most extensively for ignitable-liquid residue analyses and isotope ratio analysis. This review attempts to capture the trends, motivating forces, and likely impact of developing areas of forensic mass spectrometry, with the caveat that none of this research is likely to have any real impact in the forensic community unless: (a) The instruments developed are turned into robust black boxes with red and green lights for positives and negatives, respectively, or (b) there are PhD graduates in the workforce who can help adopt these sophisticated techniques.