Erythrocyte preservation. VI. The storage of blood with purine nucleosides.
Erythrocyte preservation. VI. The storage of blood with purine nucleosides.
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红细胞保存。
DOI：
10.1172/jci103309
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发表时间：
1956
期刊：
影响因子：
--
通讯作者：
B. W. Gabrio
中科院分区：
文献类型：
--
作者：
D. M. Donohue;C. Finch;B. W. Gabrio
在储存的血液中添加腺苷可以对恶化的红细胞进行化学修复，并在持续储存期间维持其活力 (1, 2)。这种现象被称为储存生化损伤的体外可逆性。除了该反应对红细胞代谢的影响 (3) 之外，评估腺苷在血液保存中的作用似乎也很重要。本研究表明，腺苷和一些相关的嘌呤核苷可延缓储存病变的发生，并显着延长储存血液的存活时间。讨论了这些补充剂的有效浓度及其潜在毒性。
The addition of adenosine to stored blood results in a chemical restoration of deteriorated erythrocytes and sustains their viability during continued storage (1, 2). This phenomenon has been referred to as the in vitro reversibility of a biochemical lesion of storage. Apart from the implications of this reaction in red cell metabolism (3), it seemed of importance to evaluate the effect of adenosine in the preservation of blood. The present study indicates that adenosine and some related purine nucleosides retard the onset of the storage lesion and extend significantly the period of viability of stored blood. The effective concentration of these supplements, as well as their potential toxicity, is discussed.