Stress, NK cells, and cancer: Still a promissory note
Stress, NK cells, and cancer: Still a promissory note
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DOI：
10.1016/j.bbi.2007.06.008
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发表时间：
2007-10-01
影响因子：
15.1
通讯作者：
Schleifer, Steven J.
中科院分区：
文献类型：
--
作者：
Ben-Eliyahu, Shamgar;Page, Gayle G.;Schleifer, Steven J.
虽然过去几十年来已经提供了大量的证据表明压力对免疫和癌症发展的有害影响，并提出了介导机制，但没有心理神经免疫学（PNI）相关的干预措施已成为传统癌症治疗的标准护理。我们认为其原因包括癌症演变的独特性质和与免疫系统的相互作用，以及研究应激对免疫活性的影响及其对人类抵抗恶性肿瘤的影响的许多概念和技术障碍。然而，恶性组织和免疫细胞之间的众多和不同的相互作用，现在更好地理解，并建议可以在癌症PNI研究中进行调查的某些关键时期。癌症进展的动物模型有助于提示对癌症进展的特定方面的应激效应的神经内分泌和免疫介质，特别是关于NK细胞活性的作用。然而，最终的临床相关性必须在癌症患者中进行测试。最近的动物研究表明交感神经系统在介导对免疫和肿瘤进展的生物相关应激效应中的作用。现在可以在患者身上测试相关的干预措施，以支持或反驳此类研究的承诺。(C)2007年由Elsevier Inc.出版
Although the last decades have provided ample evidence for deleterious effects of stress on immunity and on cancer development and suggested mediating mechanisms, no psychoneuroimmunology (PNI)-related intervention has become a standard of care in conventional cancer treatment. We believe the reasons for this include the unique nature of cancer evolvement and interactions with the immune system, and the many conceptual and technical obstacles to studying stress effects on immune activity and their implications for human resistance to malignancy. However, the numerous and diverse interactions between malignant tissue and immunocytes are now better understood, and suggestions can be made with respect to certain critical periods to be investigated in cancer-PNI research. Animal models of cancer progression are instrumental in suggesting neuroendocrine and immunological mediators of stress effects on specific aspects of cancer progression, especially with respect to the role of NK cell activity. The ultimate clinical relevance, however, must be tested in cancer patients. Recent animal studies suggest a role for the sympathetic nervous system in mediating biologically relevant stress effects on immunity and on tumor progression. Related interventions can now be tested in patients to support or refute the promise of such studies. (C) 2007 Published by Elsevier Inc.