Cytokine profile in degenerated painful intervertebral disc: variability with respect to duration of symptoms and type of disease
Cytokine profile in degenerated painful intervertebral disc: variability with respect to duration of symptoms and type of disease
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DOI：
10.1016/j.spinee.2016.03.019
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发表时间：
2016-07-01
期刊：
影响因子：
4.5
通讯作者：
Altun, Idiris
中科院分区：
文献类型：
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作者：
Altun, Idiris
背景：神经炎症被认为在慢性疼痛的产生中发挥着至关重要的作用。许多试验已经证明促炎细胞因子在与外周和中枢伤害感受相关的疼痛病理生理学中的作用。促炎细胞因子的局部和全身表达被认为是疼痛的介质。在这些细胞因子中，肿瘤坏死因子-α (TNF-α)、白细胞介素 1 β (IL-1 β) 和白细胞介素 6 (IL-6) 尤其值得注意，因为它们在神经损伤后具有痛觉过敏作用。 目的：本研究的目的是评估和比较 IL-1 β、IL-6 和白细胞介素 10 的组织水平 (IL-10) 和 TNF-α 存在于急性期和慢性期退变椎间盘的韧带下和游离片段类型中。研究设计：这是一项横断面研究。患者样本：对平均年龄为 38.2 +/- 4.9 岁、通过显微椎间盘切除术进行手术治疗的总共 49 名患者（24 名女性，25 名男性）进行了横断面研究。 措施：在这些病例中，19 例患者主诉时间少于 6 个月，而 30 例患者腰痛和腿痛时间超过 6 个月。 38 例患者被诊断为韧带下型，11 例患者为游离碎片型椎间盘退变。 方法：对显微椎间盘切除术中获得的髓核组织制备的组织样本中的 IL-1β、IL-6、IL-10 和 TNF-α 水平进行评估。对急性和慢性主诉持续时间以及韧带下型和游离碎片型椎间盘退变患者的结果进行比较。 结果：IL-1β 水平（p
BACKGROUND CONTEXT: Neuroinflammation is supposed to play a crucial role in the generation of chronic pain. Numerous trials have documented the contribution of proinflammatory cytokines in the pathophysiology of pain associated with peripheral and central nociception. Local and systemic expressions of proinflammatory cytokines have been implicated as mediators of pain. Among these cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) are especially notable because of their hyperalgesic impacts after nerve damage.PURPOSE: The aim of the present study was to evaluate and compare the tissue levels of IL-1 beta, IL-6, interleukin-10 (IL-10), and TNF-alpha in subligamentous and free fragment types of degenerated intervertebral disc in acute and chronic periods.STUDY DESIGN: This was a cross-sectional study.PATIENT SAMPLE: A cross-sectional study was implemented on a total of 49 patients (24 women, 25 men) with an average age of 38.2 +/- 4.9 treated surgically by means of microdiscectomy.OUTCOME MEASURES: Of these cases, 19 had complaints for less than 6 months, whereas 30 patients had been suffering from low back pain and leg pain for more than 6 months. Thirty-eight patients have been diagnosed with subligamentous type and 11 patients had free fragment type of disc degeneration.METHODS: The levels of IL-1 beta, IL-6, IL-10, and TNF-alpha were assessed in tissue samples prepared from nucleus pulposus tissue obtained during microdiscectomy. Results were compared in patients with acute and chronic duration of complaints, as well as subligamentous and free fragment types of intervertebral disc degeneration.RESULTS: The levels of IL-1 beta (p