Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension
Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension
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DOI：
10.1183/09031936.00174908
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发表时间：
2009-09-01
影响因子：
24.3
通讯作者：
Rundqvist, B.
中科院分区：
文献类型：
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作者：
Selimovic, N.;Bergh, C-H.;Rundqvist, B.
本研究的目的是评估肺动脉高压（PAH）患者肺循环中生长因子和白细胞介素(IL)-6的水平，并将其与临床和血流动力学数据和结果联系起来。在右心导管术中同时采集PAH患者（n=44）和对照组（n=20）的动脉和肺动脉血样。ELISA法检测血管内皮生长因子（VEGF）、血小板源性生长因子(PDGF)-BB、转化生长因子(TGF)- β 1、IL-6水平。血管内皮生长因子、PDGF-BB、tgf - β 1和IL-6的动脉中位值（四分位数范围）在患者中显著升高(377（218-588）比9.0 pg.mL(-1)；1955 (1,371-2,519) vs 306 (131-502) pg.mL(-1)；26.42(11.3 - -41.1)和7.0 (1.8 - -18.4)ng.mL (1);3.98 (0.7-8.1) vs 0.7 pg.mL(-1)；p
The aim of our study was to assess the levels of growth factors and interleukin (IL)-6 across the pulmonary circulation in patients with pulmonary arterial hypertension (PAH) and correlate them with clinical and haemodynamic data and outcome.Simultaneous arterial and pulmonary arterial blood samples in patients with PAH (n=44) and controls (n=20) were obtained during right heart catheterisation. Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)-BB, transforming growth factor (TGF)-beta 1 and IL-6 were measured using ELISA.Arterial median (interquartile range) values for VEGF, PDGF-BB, TGF-beta 1 and IL-6 were significantly higher in patients (377 (218-588) versus 9.0 pg.mL(-1); 1,955 (1,371-2,519) versus 306 (131-502) pg.mL(-1); 26.42 (11.3-41.1) versus 7.0 (1.8-18.4) ng.mL(-1); and 3.98 (0.7-8.1) versus 0.7 pg.mL(-1), respectively; p