Maternal exposure to nitrate from drinking water and diet and risk for neural tube defects
Maternal exposure to nitrate from drinking water and diet and risk for neural tube defects
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DOI：
10.1093/aje/153.4.325
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发表时间：
2001-02-15
影响因子：
5
通讯作者：
Shaw, GM
中科院分区：
文献类型：
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作者：
Croen, LA;Todoroff, K;Shaw, GM
1989年6月至1991年5月在加州进行的这项以人群为基础的病例对照研究中，作者调查了母亲围受孕期暴露于饮用水和饮食中的硝酸盐与神经管缺陷风险之间的关系。对538例病例和539例非畸形对照的母亲进行了有关居住史、家中自来水消耗量和围受孕期饮食摄入量的访谈。饮食中的硝酸盐暴露与神经管缺陷的风险增加无关。暴露于饮用水中硝酸盐浓度高于45毫克/升的最大污染水平与无脑畸形的风险增加有关（比值比（OR）= 4.0，95%置信区间（CI）：1.0，15.4），但与脊柱裂无关。仅在饮用地下水的人群中，当硝酸盐水平低于最大污染水平时，观察到无脑畸形的风险增加（OR = 2.1，95% CI：5-15 mg/L为1.1，4.1; OR = 2.3，95% CI：1.1，16-35 mg/L为4.5; OR = 6.9，95% CI：36-67毫克/升为1.9，24.9，
In this population-based case-control study conducted in California between June 1989 and May 1991, the authors investigated the association between maternal periconceptional exposure to nitrate from drinking water and diet and risk for neural tube defects. The mothers of 538 cases and 539 nonmalformed controls were interviewed regarding residential history, consumption of tap water at home, and dietary intake during the periconceptional period. Dietary nitrate exposure was not associated with increased risk for neural tube defects. Exposure to nitrate in drinking water at concentrations above the 45 mg/liter maximum contaminant level was associated with increased risk for anencephaly (odds ratio (OR) = 4.0, 95% confidence interval (CI): 1.0, 15.4), but not for spina bifida. Increased risks for anencephaly were observed at nitrate levels below the maximum contaminant level among groundwater drinkers only (OR = 2.1, 95% CI: 1.1, 4.1 for 5-15 mg/liter; OR = 2.3, 95% CI: 1.1, 4.5 for 16-35 mg/liter; and OR = 6.9, 95% CI: 1.9, 24.9 for 36-67 mg/liter compared with