Dose response curve for the phase-shifting effect of triazolam on the mammalian circadian clock.
Dose response curve for the phase-shifting effect of triazolam on the mammalian circadian clock.
复制标题
三唑仑对哺乳动物生物钟的相移作用的剂量响应曲线。
DOI：
10.1016/0024-3205(87)90564-9
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发表时间：
1987
期刊：
影响因子：
6.1
通讯作者：
Losee-Olson,SH
中科院分区：
文献类型：
--
作者：
Turek,FW;Losee-Olson,SH
对金仓鼠测量了三唑仑（一种常用于治疗失眠的短效苯二氮卓类药物）对运动活动昼夜节律的相移作用的剂量反应曲线。在轮跑活动开始前六小时腹腔内单次注射三唑仑会导致节律出现剂量依赖性相位提前。在注射 0.5 至 5.0 毫克三唑仑的动物中观察到最大相位提前，平均约为 100 分钟。使用促进睡眠并诱导中央生物钟相移的药物，对于治疗与时间表打乱相关的睡眠障碍以及与异常昼夜节律相关的精神和身体疾病可能很重要。
A dose response curve for the phase shifting effect of triazolam, a short-acting benzodiazepine commonly prescribed for the treatment of insomnia, on the circadian rhythm of locomotor activity was measured for the golden hamster. A single intraperitoneal injection of triazolam six hours before the onset of wheel-running activity induced a dose-dependent phase advance in the rhythm. A maximum phase advance, which averaged about 100 minutes, was observed in animals injected with 0.5 to 5.0 mg of triazolam. The use of drugs which promote sleep, and induce phase shifts in a central circadian clock, could be important in the treatment of sleep disorders associated with disrupted schedules and of mental and physical disorders associated with abnormal circadian rhythmicity.