Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis.
Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis.
复制标题
影响砷暴露人体砷甲基化的因素：系统评价和荟萃分析
DOI：
10.3390/ijerph13020205
复制
发表时间：
2016-02-06
影响因子：
--
通讯作者：
Jing M
中科院分区：
文献类型：
--
作者：
Shen H;Niu Q;Xu M;Rui D;Xu S;Feng G;Ding Y;Li S;Jing M
在许多国家，慢性砷暴露是一个严重的公共卫生问题。砷在体内的代谢是复杂的，受多种因素的影响。在本次荟萃分析中，两位研究人员独立检索了Cochrane图书馆、PubMed、Springer、Embase和中国国家知识基础设施等电子数据库，以分析影响砷甲基化的因素。接触砷后，以下砷代谢物的浓度会增加 (p< 0.000001)：无机砷 (iAs)、一甲基砷 (MMA)、二甲基砷 (DMA) 和总砷。此外，iAs（标准平均差（SMD）：1.00；95%置信区间（CI）：0.60-1.40；p<0.00001）和MMA（SMD：0.49；95% CI：0.21-0.77；p = 0.0006）的百分比也增加，而DMA（SMD：-0.57；p = 0.0006）的百分比也增加。 95% CI：-0.80–-0.31；p< 0.0001），初级甲基化指数（SMD：-0.57；95% CI：-0.94–-0.20；p = 0.002）和次级甲基化指数（SMD：-0.27；95% CI：-0.46–0.90；p = 0.004）降低。吸烟、饮酒和年龄较大可以降低砷甲基化，并且砷甲基化在女性中比男性更有效。该分析的结果可以提供有关砷氧化甲基化在砷中毒过程中的作用的信息。
Chronic arsenic exposure is a critical public health issue in many countries. The metabolism of arsenic in vivo is complicated because it can be influenced by many factors. In the present meta-analysis, two researchers independently searched electronic databases, including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze factors influencing arsenic methylation. The concentrations of the following arsenic metabolites increase (p< 0.000001) following arsenic exposure: inorganic arsenic (iAs), monomethyl arsenic (MMA), dimethyl arsenic (DMA), and total arsenic. Additionally, the percentages of iAs (standard mean difference (SMD): 1.00; 95% confidence interval (CI): 0.60–1.40; p< 0.00001) and MMA (SMD: 0.49; 95% CI: 0.21–0.77; p = 0.0006) also increase, while the percentage of DMA (SMD: −0.57; 95% CI: −0.80–−0.31; p< 0.0001), primary methylation index (SMD: −0.57; 95% CI: −0.94–−0.20; p = 0.002), and secondary methylation index (SMD: −0.27; 95% CI: −0.46–−0.90; p = 0.004) decrease. Smoking, drinking, and older age can reduce arsenic methylation, and arsenic methylation is more efficient in women than in men. The results of this analysis may provide information regarding the role of arsenic oxidative methylation in the arsenic poisoning process.