Adolescent and young adult (AYA) lymphoma survivors report lower health-related quality of life compared to a normative population: results from the PROFILES registry
Adolescent and young adult (AYA) lymphoma survivors report lower health-related quality of life compared to a normative population: results from the PROFILES registry
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DOI：
10.1080/0284186x.2016.1267404
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发表时间：
2017-02-01
期刊：
影响因子：
3.1
通讯作者：
van de Poll-Franse, Lonneke V.
中科院分区：
文献类型：
--
作者：
Husson, Olga;Prins, Judith B.;van de Poll-Franse, Lonneke V.
背景资料：试图同时实现发育里程碑和科普危及生命的疾病可能会使青少年和年轻人（AYAs）在以后的生活中面临健康相关生活质量（HRQoL）受损的风险。本研究的目的是检查AYA淋巴瘤幸存者和正常人群之间的HRQoL的差异，并确定社会人口统计学，临床和长期的与HRQoL.Material和方法相关的因素：本研究是一个纵向的，以人口为基础的调查在1999年和2012年之间诊断的淋巴瘤幸存者。将AYA幸存者样本（诊断时年龄为18-39岁）与性别和年龄匹配的正常人群的HRQoL（EORTC-QLQ-C30）和心理困扰（HADS）进行比较。进行多元线性回归分析，以确定与HRQoL之间survivors.Results相关的因素：一百九十八AYA淋巴瘤幸存者（58%）响应研究邀请。与年龄和性别匹配的正常人群（N=380）相比，AYA淋巴瘤幸存者在HRQoL的七个特定领域（身体、角色、认知、情感、社会功能、疲劳和经济困难）中观察到显著且临床相关的HRQoL较差（所有P
Background: Trying to simultaneously achieve developmental milestones and cope with a life-threatening disease may place adolescents and young adults (AYAs) at risk for impaired health-related quality of life (HRQoL) later in life. The aim of this study was to examine differences in HRQoL between AYA lymphoma survivors and a normative population and to determine sociodemographic, clinical and long-term symptom-related factors associated with HRQoL.Material and methods: This study was part of a longitudinal, population-based survey among lymphoma survivors diagnosed between 1999 and 2012. The AYA survivor sample (18-39 years at time diagnosis) was compared to a sex- and age-matched normative population on HRQoL (EORTC-QLQ-C30) and psychological distress (HADS). Multiple linear regression analyses were conducted to determine factors associated with HRQoL among survivors.Results: One hundred and ninety-eight AYA lymphoma survivors (58%) responded to the study invitation. Compared to an age- and sex-matched normative population (N=380), significantly and clinically relevant poorer HRQoL was observed for AYA lymphoma survivors in seven specific domains of HRQoL: physical, role, cognitive, emotional, social functioning, fatigue and financial difficulties (all p