A comparative study, of nonspecific depressive symptoms and minor depression regarding functional impairment and associated characteristics in primary care
A comparative study, of nonspecific depressive symptoms and minor depression regarding functional impairment and associated characteristics in primary care
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DOI：
10.1016/j.comppsych.2005.04.007
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发表时间：
2006-01-01
影响因子：
7.3
通讯作者：
Kronmüller, KT
中科院分区：
文献类型：
--
作者：
Backenstrass, M;Frank, A;Kronmüller, KT
背景：轻度抑郁症在临床和初级保健中非常普遍。然而，目前仍不清楚各种阈值下综合征之间是否存在可区分的组，以及它们在多大程度上与损害有关，因此需要治疗。因此，本研究旨在比较两组阈值下抑郁症患者(非特异性抑郁症和轻度抑郁症)与非抑郁症患者和重度抑郁症患者的损害程度。本研究的另一个目的是评估抑郁综合征的谱系假说。样本和方法：使用自填式患者健康问卷(PHQ)对619名初级保健患者的样本进行研究。在一个标准的基础上定义了阈值下抑郁综合征，比较了非抑郁组、阈值下抑郁组和重度抑郁症患者的频率、社会人口学因素和损害程度。结果：91%的研究对象诊断出非特异性抑郁症状(NDS)，6.2%的患者诊断为轻度抑郁症。在年龄等社会人口学风险因素方面，阈值下抑郁障碍患者彼此之间没有差异，也没有与重度抑郁症患者不同。性别，或婚姻状况。然而，可以发现从NDS到轻度抑郁症再到重度抑郁症的损害程度不断增加。结论：研究结果符合抑郁综合征从NDS到轻度抑郁症再到重度抑郁症的谱系假说。亚症候群抑郁症患者表现出严重的功能障碍，其中至少有一些患者可能有需要治疗的障碍。(C)2005 Elsevier Inc.保留所有权利。
Background: Milder forms of depression are highly prevalent in the clinical setting as well as in primary care. However, it is still unclear whether there are distinguishable groups among the various subthreshold syndromes and to what extent they are associated with impairment, thus requiring treatment. Therefore, the study aimed at comparing the degree of impairment in 2 groups of subthreshold depressive patients (nonspecific and minor depressive) with nondepressive patients and with major depressive patients. Another aim of the study was to evaluate the spectrum hypothesis of depressive syndromes.Sampling and methods: A sample of 619 primary care patients was studied using the self-administered Patient Health Questionnaire (PHQ). After defining subthreshold depressive syndromes on a criterion basis, frequencies, sociodemographic factors, and impairment of nondepressive, subthreshold depressive, and major depressive patients were compared.Results: Nonspecific depressive symptoms (NDS) were diagnosed in 9.1 % of the study subjects and minor depression in 6.2%. Subjects with subthreshold depressive disorders did not differ from each other or from subjects with major depression regarding sociodemographic risk factors such as age,. sex, or marital status. Yet, a continually increasing impairment from NDS to minor depression to major depression could be found. Moreover, the investigated groups differed with regard to the severity index.Conclusions: The results of the study are in accordance with the spectrum hypothesis of depressive syndromes ranging from NDS to minor depression to majors depression. Patients with subsyndromal depression showed significant functional impairment to the extent that at least some of these patients probably had a disorder requiring treatment. (c) 2005 Elsevier Inc. All rights reserved.