Neuroimmunological findings of Angiostrongylus cantonensis meningitis in ecuadorian patients
Neuroimmunological findings of Angiostrongylus cantonensis meningitis in ecuadorian patients
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DOI：
10.1590/s0004-282x2011000400011
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发表时间：
2011-06-01
影响因子：
1.4
通讯作者：
Bu-Coifiu- Fanego, Raisa
中科院分区：
文献类型：
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作者：
Dorta-Contreras, Alberto J.;Padilla-Docal, Barbara;Bu-Coifiu- Fanego, Raisa
最近在厄瓜多尔亚热带地区首次暴发的患者中报告了由广州管圆线虫引起的脑膜炎。方法：对两次暴发的8例青壮年患者进行研究。定量脑脊液和血清中的伊加、IgM、IgG和白蛋白，并绘制脑脊液/血清商图（Reibergrams）。对病人的回忆包括询问是否食用过生蜗牛、症状和造成的伤害。结果如下：观察到血清和脑脊液中平均嗜酸性粒细胞分别为7.5%和26%，以及总蛋白中度增加。在三类免疫球蛋白中观察到最常见的鞘内合成模式。在所有病例中，在首次症状出现后两周观察到鞘内IgM合成。结论：经脑脊液分析，广州管圆线虫引起的嗜酸性粒细胞脑膜炎的鞘内合成模式与国外的病例相似。关键词：广州管圆线虫，厄瓜多尔，嗜酸性粒细胞增多，鞘内合成，脑膜炎，Reibergram。
Meningitis caused by Angiostrongylus cantonensis has recently been reported in patients resulting from the first outbreaks in subtropical regions of Ecuador. Method: Eight young adult patients from the two outbreaks were studied. IgA, IgM, IgG and albumin in cerebrospinal fluid and serum were quantified and plotted in cerebrospinal fluid/serum quotient diagrams (Reibergrams). The anamnesis on the patients included asking about any consumption of raw snails, symptoms and harm caused. Results: Mean eosinophilia of 7.5% and 26% in serum and cerebrospinal fluid respectively was observed, as well as a moderate increase in total proteins. The most frequent pattern of intrathecal synthesis was observed in three classes of immunoglobulins. Intrathecal synthesis of IgM was observed in all cases two weeks after the first symptoms appeared. Conclusion: The intrathecal synthesis patterns of eosinophilic meningitis due to Angiostrongylus cantonensis, facilitated by cerebrospinal fluid analysis, were similar to those of previous cases from abroad. Key words: Angiostrongylus cantonensis, Ecuador, eosinophilia, intrathecal synthesis, meningitis, Reibergram.