H-1-NMR STUDIES OF HUMAN-BLOOD PLASMA ASSIGNMENT OF RESONANCES FOR LIPOPROTEINS
H-1-NMR STUDIES OF HUMAN-BLOOD PLASMA ASSIGNMENT OF RESONANCES FOR LIPOPROTEINS
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DOI：
10.1016/0014-5793(87)81224-3
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发表时间：
1987-07-13
期刊：
影响因子：
3.5
通讯作者：
LAVILLE, A
中科院分区：
文献类型：
--
作者：
BELL, JD;SADLER, PJ;LAVILLE, A
报告了人血浆和分离乳糜微粒、VLDL、LDL和HDL的单脉冲和Hahn自旋回波500 MHz 1H NMR光谱。比较已使具体的分配，以作出共振的个别脂蛋白在CH 2和CH 3（脂肪酸），和NMe+3（磷脂胆碱头基）地区的血浆光谱（0.8-1.3和1.25 ppm，分别）。血浆样本的禁食和冻融导致脂质共振的强度和线宽发生显著变化。在血浆光谱中的脂质共振的分析，在个人的脂蛋白可能会揭示新的光在许多条件下的临床和生物化学的利益。
Single‐pulse and Hahn spin‐echo 500 MHz1H NMR spectra of human blood plasma and isolated chylomicrons, VLDL, LDL and HDL are reported. The comparison has enabled specific assignments to be made for the resonances of individual lipoproteins in the CH2and CH3(fatty acid), and NMe+3(phospholipid choline head group) regions of the spectra of plasma (0.8–1.3 and ∼ 3.25 ppm, respectively). Fasting, and freeze‐thawing of plasma samples led to marked changes in the intensities and linewidths of lipid resonances. Analysis of lipid resonances in the spectra of plasma in terms of individual lipoproteins may shed new light on many conditions of clinical and biochemical interest.