The use of bone allografts for limb salvage in high-grade extremity osteosarcoma.
The use of bone allografts for limb salvage in high-grade extremity osteosarcoma.
复制标题
使用同种异体骨移植来保肢高级别肢体骨肉瘤。
DOI：
10.1097/00003086-199109000-00025
复制
发表时间：
1991
影响因子：
4.2
通讯作者：
H. J. Mankin
中科院分区：
文献类型：
--
作者：
Mark C. Gebhardt;Daniel I. Flugstad;D. Springfield;H. J. Mankin
保肢手术越来越多地应用于四肢高级别骨肉瘤的局部治疗。用于重建肿瘤切除后骨缺损的同种异体骨移植物提供了许多优点，包括关节重建和在这些相对年轻的患者中将移植物并入宿主骨。对53例30岁或以下患者的结果进行了评估，以确定功能结局。新鲜冷冻同种异体移植物被用作骨关节移植物、同种异体移植物-关节融合术、同种异体移植物-假体复合物或夹层移植物。随访时间平均为25个月（范围：2至63个月）。寿命表分析显示，如果排除局部肿瘤复发，满意的功能结果的概率为73%。并发症包括16例感染、6例骨折、12例骨不连和6例关节不稳定。有5例局部复发。18例移植物最终失败，6例患者导致膝上截肢。另外5人接受了第二次移植。38例随访两年或两年以上的患者的功能“最终结果”在没有局部复发的患者中有70%令人满意。接受术前化疗的患者在功能结局或局部或远处复发方面无统计学显著差异。作者得出结论，同种异体移植物可用于接受积极辅助化疗的高级别骨肉瘤患者的肢体重建。功能结果与其他重建方法相当，并且一旦被宿主纳入，与金属植入物相比，具有寿命长的优势。
Limb preservation is increasingly being employed in the local treatment of high-grade extremity osteosarcoma. Bone allografts used to reconstruct the bony defects following tumor resection offer many advantages, including joint reconstruction and incorporation of the graft to the host bone in these relatively young patients. The results of 53 patients 30 years of age or younger were assessed to determine functional outcome. Fresh-frozen allografts were employed as osteoarticular grafts, allograft-arthrodeses, allograft-prosthesis composites, or intercalary grafts. Follow-up intervals averaged 25 months (range, two to 63 months). Life-table analysis showed that the probability of a satisfactory functional result was 73% if local tumor recurrences were excluded. Complications included 16 infections, six fractures, 12 nonunions, and six unstable joints. There were five local recurrences. Eighteen grafts ultimately failed, and in six patients, this resulted in an above-knee amputation. An additional five received a second graft. The functional "end results" of the 38 patients with two or more years of follow-up examinations were 70% satisfactory in those without a local recurrence. There was no statistically significant difference in functional outcome or local or distant relapse in those patients receiving preoperative chemotherapy. The authors conclude that allografts can be used for limb reconstruction in patients with high-grade osteosarcoma who receive aggressive adjuvant chemotherapy. The functional results are comparable to other methods of reconstruction, and once incorporated by the host, offer the advantage of longevity, compared with metallic implants.
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影响因子：
4.2
作者：
Tomford,WW;Mankin,HJ
通讯作者：
Mankin,HJ
DOI：
10.2106/00004623-199072060-00005
发表时间：
1990-07-01
影响因子：
5.3
作者：
BERREY, BH;LORD, CF;MANKIN, HJ
通讯作者：
MANKIN, HJ
使用冷冻尸体同种异体移植物治疗四肢骨肿瘤患者。
DOI：
--
发表时间：
1987
期刊：
The Orthopedic clinics of North America
影响因子：
--
作者：
Mankin,HJ;Gebhardt,MC;Tomford,WW
通讯作者：
Tomford,WW
影响因子：
158.5
作者：
LINK, MP;GOORIN, AM;VIETTI, TJ
通讯作者：
VIETTI, TJ
影响因子：
45.3
作者：
GOORIN, AM;PEREZATAYDE, A;ABELSON, HT
通讯作者：
ABELSON, HT