Brain regions responsible for the expression of conditioned taste aversion in rats
Brain regions responsible for the expression of conditioned taste aversion in rats
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DOI：
10.1093/chemse/bjj045
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Yamamoto, Takashi
中科院分区：
文献类型：
--
作者：
Yamamoto, Takashi
条件性味觉厌恶（CTA）是在摄入食物后感到不适时获得的。CTA是一种恐惧学习，使动物避免随后的食物摄入，并对食物的味道表现出厌恶行为。为了阐明负责CTA表达的脑区，我们以前的电生理和最近的c-fos免疫组织化学研究进行了审查。在包括臂旁核、杏仁核、岛叶皮质、乳头体上核、延髓核和腹侧苍白球在内的参与CTA表达的不同阶段的多种脑区中，增强的味觉敏感性以促进对条件刺激的检测可能起源于杏仁核的中央核，可能起源于杏仁核的基底外侧核。
Conditioned taste aversion (CTA) is acquired when the ingestion of a food is followed by malaise. CTA is a kind of fear learning making animals avoid subsequent intake of the food and show aversive behavior to the taste of the food. To elucidate the brain regions responsible for the expression of CTA, our previous electrophysiological and recent c-fos immunohistochemical studies have been reviewed. Among a variety of brain regions including the parabrachial nucleus, amygdala, insular cortex, supramammillary nucleus, nucleus accumbens, and ventral pallidum that are involved in different phases of CTA expression, the enhanced taste sensitivity to facilitate detection of the conditioned stimulus may originate in the central nucleus of the amygdala and the hedonic shift, from positive to negative, may originate in the basolateral nucleus of the amygdala.