Diabetes, impaired fasting glucose, and elevated HbA1c in US adolescents:: The Third National Health and Nutrition Examination Survey
Diabetes, impaired fasting glucose, and elevated HbA1c in US adolescents:: The Third National Health and Nutrition Examination Survey
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DOI：
10.2337/diacare.24.5.834
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发表时间：
2001-05-01
期刊：
影响因子：
16.2
通讯作者：
Beckles, GLA
中科院分区：
文献类型：
--
作者：
Fagot-Campagna, A;Saaddine, JB;Beckles, GLA
目的--使用基于人群的数据，我们估计了美国青少年糖尿病、空腹血糖受损和HbA（1c）水平升高（>6%）的患病率。（1988-1994）研究了美国人口的代表性样本，其中包括2，867名12-19岁的青少年进行了血清葡萄糖测定。结果-样本中共有13名青少年被认为患有糖尿病：9例报告使用胰岛素，2例报告仅使用口服药物，2例未报告任何治疗，但血糖水平较高（≥ 11.1 mmol/l，无论空腹时间长短，或空腹8小时后≥ 7.0 mmol/l）。其中4例（占糖尿病患者样本的31%）被认为患有2型糖尿病。每100名12-19岁青少年的糖尿病（所有类型）患病率估计为0.41%（95%置信区间0-0.86）。空腹血糖受损（≥ 6.1 mmol/l）的患病率为1.76%（0.02-3.50），其中未患糖尿病的青少年中至少有8 h的空腹血糖受损。HbA（1c）升高（>6%）的患病率为0.39%（0.04-0.74）。结论--国家数据反映了美国青少年中存在2型糖尿病，但由于患病率相对较低，调查样本量不够大，无法获得精确的患病率估计。
OBJECTIVE - Using population based data, we estimated the prevalence of diabetes, impaired fasting glucose, and elevated HbA(1c) (>6%) levels in U.S. adolescents.RESEARCH DESIGN AND METHODS - The Third National Health and Nutrition Examination Survey (1988-1994) examined a representative sample of the U.S. population, which included 2,867 adolescents aged 12-19 years who had serum glucose measured.RESULTS - A total of 13 adolescents in the: sample were considered to have diabetes: 9 reported using insulin, 2 reported using oral agents only, and 2 did not report any treatment but had high glucose levels (greater than or equal to 11.1 mmol/l regardless of length of fast or greater than or equal to7.0 mmol/l after an 8-h fast). Four of these cases (31% of the sample with diabetes) were considered to have type 2 diabetes. The estimated prevalence of diabetes (all types) per 100 adolescents ages 12-19 years was 0.41% (95% confidence interval 0-0.86). The prevalence of impaired fasting glucose (greater than or equal to6.1 mmol/l) among adolescents without diabetes who had tasted for at least 8 h was 1.76% (0.02-3.50). The prevalence of elevated HbA(1c) (>6%) was 0.39% (0.04-0.74).CONCLUSIONS - National data reflect the presence of type 2 diabetes in U.S. adolescents, but the survey sample size was not large enough to obtain precise prevalence estimates because of the relatively low prevalence.