Assessment of iron deficiency in the context of the obesity epidemic: importance of correcting serum ferritin concentrations for inflammation
Assessment of iron deficiency in the context of the obesity epidemic: importance of correcting serum ferritin concentrations for inflammation
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DOI：
10.3945/ajcn.112.054551
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发表时间：
2013-09-01
影响因子：
7.1
通讯作者：
Delpeuch, Francis
中科院分区：
文献类型：
--
作者：
Gartner, Agnes;Berger, Jacques;Delpeuch, Francis
背景：最近提出了校正血清铁蛋白(SF)浓度以治疗感染性或寄生虫病引起的炎症，特别是在发展中国家，但在许多国家，肥胖已成为炎症的主要原因。目的：我们在未经校正的血清铁蛋白(SF)的基础上，全面地评估了根据肥胖状况估计铁缺乏(ID)的偏差。设计：2010年在摩洛哥拉巴特萨勒进行了一项横断面调查，随机抽取了811名年龄在20-49岁的妇女。肥胖通过身体质量指数(BMI)(单位为公斤/米(2))(正常：BMI=25至=30)进行评估，腰围和体脂。C反应蛋白(CRP)浓度2 mg/L表示炎症反应，SF浓度2 mg/L表示ID，SF校正系数为0.65。未校正SF后，ID的患病率(37.2%比45.2%；差异-8.0%，P<；0.0001)被低估，并且差异随着肥胖的增加而增加(在正常、超重和肥胖受试者中分别为-2.9%、-8.5%和-12.4%；P-交互作用和P<；0.0001)。在其他肥胖测量中也观察到了类似的结果。结论：在ID仍然普遍但肥胖率已经很高的发展中国家，即使传染病或寄生虫病不再普遍，在评估ID状态时也应该使用校正的SF。这项试验在Clinicaltrials.gov上注册为NCT01844349。
Background: The correction of serum ferritin (SF) concentrations for inflammation because of infectious or parasitic diseases was recently proposed, especially in developing countries, but in many countries, adiposity has become the main cause of inflammationObjective: We assessed, overall and by adiposity status, the bias in the estimation of iron deficiency (ID) on the basis of uncorrected SF.Design: A cross-sectional survey in 2010 in Rabat-Sale, Morocco, used a random sample of 811 women aged 20-49 y. Adiposity was assessed by body mass index (BMI) (in kg/m(2)) (normal: BMI = 25 to = 30), waist circumference, and body fat. Inflammation was indicated by a C-reactive protein (CRP) concentration >2 mg/L. ID was indicated by an SF concentration 2 mg/L. The correction factor of SF was 0.65. The prevalence of ID (37.2% compared with 45.2%; difference -8.0%, P < 0.0001) was underestimated by not correcting SF, and the difference increased with adiposity (-2.9%, -8.5%, and -12.4% in normal, overweight, and obese subjects, respectively; P-interaction < 0.0001). Analogous results were observed for other adiposity measures.Conclusion: In developing countries where ID remains prevalent but rates of obesity are already high, corrected SF should be used when assessing ID status, even if infectious or parasitic diseases are no longer widespread. This trial was registered at clinicaltrials.gov as NCT01844349.