Neuroendocrine tumors producing calcitonin: characteristics, prognosis and potential interest of calcitonin monitoring during follow-up.
Neuroendocrine tumors producing calcitonin: characteristics, prognosis and potential interest of calcitonin monitoring during follow-up.
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DOI：
10.1530/eje-15-0917
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发表时间：
2016-03
影响因子：
5.8
通讯作者：
C. Nozières;L. Chardon;B. Goichot;F. Borson‐Chazot;V. Hervieu;K. Chikh;C. Lombard-Bohas;T. Walter
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文献类型：
--
作者：
C. Nozières;L. Chardon;B. Goichot;F. Borson‐Chazot;V. Hervieu;K. Chikh;C. Lombard-Bohas;T. Walter
降钙素（CT）释放不当是甲状腺髓样癌（MTC）的主要特征，可能发生在神经内分泌肿瘤（NET）中。这项回顾性研究的目的是评估i）CT产生NET的特征和预后，以及ii）随访期间CT监测的价值。方法纳入2010年至2012年期间检测血清CT的所有NETs患者。排除了MTC。研究了其临床、生物学和组织学特征。结果176例患者中有21例（12%）血清CT浓度>100 ng/l，肿瘤主要为支气管或胰腺源性（P <100 ng/l），8例患者记录到可能归因于CT的症状，在其他分泌综合征中偶尔与类癌综合征重叠。免疫组化可在6个肿瘤标本，CT检测5。在11例连续5次或更多次CT检测的患者中，激素水平与临床病程相关性相当好。结论部分NETs患者血清CT水平升高，尤其是前肠源性NETs和高级别NETs患者。随访期间CT监测的建议价值必须在进一步的研究中得到证实。
OBJECTIVES Inappropriate calcitonin (CT) release, a major feature of medullary thyroid cancer (MTC), may occur in neuroendocrine tumors (NETs). The aims of this retrospective study were to assess i) the characteristics and prognosis of CT-producing NETs, and ii) the value of CT monitoring during follow-up. METHODS All patients with NETs in whom serum CT was assayed between 2010 and 2012 were included. MTCs were excluded. Clinical, biological, and histological characteristics were studied. RESULTS Twenty-one (12%) of 176 patients in whom serum CT was systematically assayed had concentrations >100 ng/l, with tumours predominantly of bronchial or pancreatic origin (P100 ng/l, symptoms potentially attributable to CT were recorded in eight, with occasional overlap with the carcinoid syndrome among other secretory syndromes. Immunohistochemistry could be performed in six tumor specimens, CT being detected in five. In 11 patients with five or more successive CT assays, hormone levels were fairly well correlated with clinical courses. CONCLUSION Serum CT levels may be raised in some patients with NETs, especially from foregut origin, and of high grade. The suggested value of CT monitoring during follow-up must be confirmed in further studies.