Mycobacterial disease in a population of 339 cats in Great Britain: II. Histopathology of 225 cases, and treatment and outcome of 184 cases
Mycobacterial disease in a population of 339 cats in Great Britain: II. Histopathology of 225 cases, and treatment and outcome of 184 cases
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DOI：
10.1016/j.jfms.2011.09.009
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发表时间：
2011-12-01
影响因子：
1.7
通讯作者：
Shaw, Darren J.
中科院分区：
文献类型：
--
作者：
Gunn-Moore, Danielle A.;McFarland, Sarah E.;Shaw, Darren J.
本研究调查了339例猫分枝杆菌感染，225例病例的组织病理学结果，184例病例的治疗和结局信息。将剖腹探查时出现皮肤病变或可疑肿块的猫的组织样本提交至兽医实验室机构进行分枝杆菌培养，为期4年，直至2008年12月。该研究审查了关于组织病理学、治疗和结局的文件信息，并在45例病例的子集中盲法审查了组织病理学变化（包括抗酸细菌[AFB]染色）。当猫被怀疑患有分枝杆菌感染时，准确识别所涉及的物种有助于确定可能的治疗方案和预后。研究证实，组织病理学和AFB的存在是识别分枝杆菌感染的有用工具。不幸的是，他们几乎没有帮助确定所涉及的分枝杆菌的种类。该研究确定了一组在初级实验室AFB阴性的猫，但可以培养出分枝杆菌;通常是牛分枝杆菌或田鼠分枝杆菌。该研究还确定了一组猫，尽管有分枝杆菌感染的典型体征和AFB染色阳性，但培养结果为阴性。许多病例对治疗反应良好（56%的病例信息可用），许多猫获得完全缓解（42%）。然而，复发是常见的（64%），通常随后是肺部和/或全身性传播，这可能是由于短期单一药物治疗造成的。这项研究表明，猫分枝杆菌病的诊断和治疗是复杂和具有挑战性的。(C)2011年ISFM和AAFP。由爱思唯尔有限公司出版。保留所有权利。
This study investigated 339 cases of feline mycobacterial infection, with histopathology findings from 225 cases, and treatment and outcome information from 184 cases. Tissue samples from cats with cutaneous lesions or suspicious masses at exploratory laparotomy were submitted to the Veterinary Laboratories Agency for mycobacterial culture over a 4-year period to December 2008. The study reviewed the files for information about histopathology, treatment and outcome, and blindly reviewed histopathological changes (including staining for acid-fast bacteria [AFB]) in a sub-set of 45 cases. When a cat is suspected of having a mycobacterial infection, accurate identification of the species involved helps to determine possible treatment options and prognosis. The study confirmed that histopathology and the presence of AFB are useful tools in the recognition of mycobacterial infection. Unfortunately, they did little to help determine the species of mycobacteria involved. The study identified a group of cats that were negative for AFB at the primary laboratory, but from which rnycobacteria could be cultured; commonly Mycobacterium bovis or Mycobacterium microti. The study also identified a group of cats which where culture negative, despite typical signs of mycobacterial infection and positive AFB staining. Many cases responded favourably to treatment (56% of the cases where information was available), and many cats gained complete remission (42%). However, relapses were common (64%) and often followed by pulmonary and/or systemic spread that may have resulted from treatment with short courses of single drugs. This study shows that the diagnosis and treatment of feline mycobacteriosis is complex and challenging. (C) 2011 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.