Magnetic nanohydroxyapatite/PVA composite hydrogels for promoted osteoblast adhesion and proliferation
Magnetic nanohydroxyapatite/PVA composite hydrogels for promoted osteoblast adhesion and proliferation
复制标题
磁性纳米羟基磷灰石/PVA复合水凝胶促进成骨细胞粘附和增殖
DOI：
10.1016/j.colsurfb.2012.10.067
复制
发表时间：
2013-03-01
影响因子：
5.8
通讯作者：
Fu, Jun
中科院分区：
文献类型：
--
作者：
Hou, Ruixia;Zhang, Guohua;Fu, Jun
This paper reports on the systematic investigation of novel magnetic nano-hydroxyapatite/PVA composite hydrogels through cyclic freeze-thawing with controllable structure, mechanical properties, and cell adhesion and proliferation properties. The content of the magnetic nano-hydroxyapatite-coated gamma-Fe2O3 (m-nHAP) particles exhibited remarkable influence on the porous structures and compressive strength of the nanocomposite hydrogels. The average pore diameter of the nanocomposite hydrogels exhibited a minimum of 1.6 +/- 0.3 mu m whereas the compressive strength reached a maximum of about 29.6 +/- 6.5 MPa with the m-nHAP content of around 10 wt% in the nanocomposite hydrogels. In order to elucidate the influence of the composite m-nHAP on the cell adhesion and proliferation on the composite hydrogels, the PVA, gamma-Fe2O3/PVA, nHAP/PVA and m-nHAP/PVA hydrogels were seeded and cultured with osteoblasts. The results demonstrated that the osteoblasts preferentially adhered to and proliferated on the m-nHAP/PVA hydrogels, in comparison to the PVA and nHAP/PVA hydrogels, whereas the gamma-Fe2O3/PVA hydrogels appeared most favorable to the osteoblasts. Moreover, with the increasing m-nHAP content in the composite hydrogels, the adhesion density and proliferation of the osteoblasts were significantly promoted, especially at the content of around 50 wt%. (c) 2012 Elsevier B.V. All rights reserved.
