BCL-2 EXPRESSION BY LEUKEMIC BLASTS IN A SCID MOUSE MODEL OF BIPHENOTYPIC LEUKEMIA ASSOCIATED WITH THE T(4-11)(Q21-Q23) TRANSLOCATION
BCL-2 EXPRESSION BY LEUKEMIC BLASTS IN A SCID MOUSE MODEL OF BIPHENOTYPIC LEUKEMIA ASSOCIATED WITH THE T(4-11)(Q21-Q23) TRANSLOCATION
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DOI：
10.1111/j.1365-2141.1995.tb05207.x
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发表时间：
1995-08-01
影响因子：
6.5
通讯作者：
COTTER, FE
中科院分区：
文献类型：
--
作者：
POCOCK, CFE;MALONE, M;COTTER, FE
婴儿急性白血病与染色体11 q23带异常有关，预后差。混合谱系白血病（MLL）的相关基因已被鉴定，并具有转录因子的特征。负责阻断程序性细胞死亡的BCL-2基因在许多血液恶性肿瘤中高度表达，包括有和无t（14;18）易位。没有易位的包括急性淋巴细胞白血病（ALL），急性髓细胞白血病（AML）和慢性淋巴细胞白血病（CLL）。在这些疾病中，BCL-2蛋白与对诱导细胞凋亡的化疗药物的耐药性有关。高BCL-2表达也与培养物中白血病原始细胞的自主生长相关，并预测预后不良，SEM细胞系使用首次复发的5岁女孩的血液淋巴母细胞建立。t（4;11）ALL表达淋巴样（CD 19）和髓样（CD 13）细胞表面标志物。在细胞培养中，细胞亚群（
Acute leukaemia of infancy is associated with abnormalities at chromosome band 11q23, and has a poor prognosis. The gene involved, Mixed Lineage Leukaemia (MLL), has been identified and has the characteristics of a transcription factor, The BCL-2 gene responsible for blocking of programmed cell death is highly expressed in a number of haematological malignancies, both with and without the t(14;18) translocation. Those without the translocation include acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML) and chronic lymphocytic leukaemia (CLL). In these diseases the BCL-2 protein is implicated in drug resistance to apoptosis-inducing chemotherapeutic agents. High BCL-2 expression is also associated with autonomous growth of leukaemic blasts in culture and predicts a poor prognosis, The SEM cell line, established using blood lymphoblasts from a 5-year-old girl in first relapse with. t(4;11) ALL, expresses lymphoid (CD19) and myeloid (CD13) cell surface markers. In cell culture, a subpopulation of cells (