Reduction of adverse acute cardiovascular actions of 6-hydroxydopamine in dogs by adrenergic receptor blockade.
Reduction of adverse acute cardiovascular actions of 6-hydroxydopamine in dogs by adrenergic receptor blockade.
复制标题
通过肾上腺素能受体阻断减少 6-羟基多巴胺对狗的不良急性心血管作用。
DOI：
10.1016/0014-2999(75)90311-8
复制
发表时间：
1975
影响因子：
5
通讯作者：
R. Peterson
中科院分区：
文献类型：
--
作者：
T. Burks;M. N. Grubb;R. Peterson
给狗注射50 mg/kg的6-羟基多巴胺（6-OHDA）引起血压和心率大幅增加，1或2小时后出现严重低血压。肾上腺素能受体阻断剂酚妥拉明和普萘洛尔的预先给药减弱了6-OHDA的高和肿胀相。酚妥拉明和普萘洛尔不能阻止去甲肾上腺素的耗竭或6-OHDA诱导的肾上腺素能纤维特征性形态学变化的发生。
Injection of dogs with 50 mg/kg of 6-hydroxydopamine (6-OHDA) caused a large increases in blood pressure and heart rate, followed after 1 or 2 hr by severe hypotension. Prior administration of the adrenergic receptor blocking agents phentolamine and propranolol attenuated both the hyper- and hypotensive phases of 6-OHDA. Phentolamine and propranolol did not prevent depletion of norepinephrine or development of the characteristic morphological changes induced in adrenergic fibers by 6-OHDA.