Corticosteroids and surfactant increase lung volumes and decrease rupture pressures of preterm rabbit lungs.
Corticosteroids and surfactant increase lung volumes and decrease rupture pressures of preterm rabbit lungs.
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皮质类固醇和表面活性剂可增加早产兔肺的肺容量并降低破裂压力。
DOI：
10.1152/jappl.1987.63.4.1616
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Jobe,A
中科院分区：
文献类型：
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作者：
ElKady,T;Jobe,A
我们测量了皮质类固醇和表面活性剂单独和联合使用对肺压力-容积关系、破裂压和破裂容积的影响。在妊娠第24天和第25天，对妊娠雌兔注射倍他米松（0.1 mg/kg/天，肌肉注射）或溶媒，并在第26天和第27天分娩胎兔。气管切开术后，将天然表面活性剂（50 mg/kg体重）经气管内滴入一半肺中。在用空气充气至40 cmH 2 O和放气的9个循环后，测量气压-容积曲线。然后将肺充满空气破裂，记录破裂体积和压力。与对照组相比，皮质类固醇和表面活性剂均引起最大肺容积增加（P <0.01）和肺破裂压降低（P <0.01）。皮质类固醇加表面活性剂对肺体积的影响是每种影响的总和，但破裂压与皮质类固醇或表面活性剂单独使用时相同。此外，表面活性剂可增加肺在放气时的稳定性，这种作用在皮质类固醇治疗组中并不明显。肺泡冲洗液和肺组织中饱和磷脂酰胆碱的测量结果表明皮质类固醇组和对照组的值相当。我们的结论是，在静态性能和破裂压力的变化大概反映了皮质类固醇引起的肺结构的变化是独立的皮质类固醇对表面活性剂池大小的影响。
We measured the effects of corticosteroids and surfactant individually and in combination on lung pressure-volume relationships, rupture pressures, and rupture volumes. Pregnant does were injected with betamethasone (0.1 mg/kg per day im) or vehicle on days 24 and 25 of gestation, and fetal rabbits were delivered on days 26 and 27. Natural surfactant (50 mg/kg body wt) was instilled intratracheally into half of the lungs after tracheotomy. After nine cycles of inflation with air to 40 cmH2O and deflation, air pressure-volume curves were measured. Then the lungs were filled with air to rupture, and rupture volume and pressure were recorded. Both corticosteroids and surfactant caused an increase in maximal lung volumes (P less than 0.01) and a decrease of lung rupture pressures (P less than 0.01) compared with controls. The effects of corticosteroids plus surfactant on lung volumes were the sum of each effect individually, but rupture pressures were the same as those for corticosteroids or surfactant alone. Surfactant, in addition, caused an increase in lung stability at deflation, an effect that was not evident in the corticosteroid-treated groups. Measurements of saturated phosphatidylcholine in alveolar washes and lung tissue indicated comparable values in the corticosteroid and control groups. We conclude that changes in static properties and rupture pressures presumably reflect changes in lung structure caused by corticosteroids that are independent of a corticosteroid effect on surfactant pool sizes.