Relation of increased leptin concentrations to history of myocardial infarction and stroke in the United States population
Relation of increased leptin concentrations to history of myocardial infarction and stroke in the United States population
复制标题
DOI：
10.1016/j.amjcard.2007.02.088
复制
发表时间：
2007-07-15
影响因子：
2.8
通讯作者：
Somers, Virend Kristen
中科院分区：
文献类型：
--
作者：
Sierra-Johnson, Justo;Romero-Corral, Abel;Somers, Virend Kristen
瘦素是一种脂肪组织衍生的激素，与心血管疾病的结局有关；然而，在美国人群中，尤其是在女性中，数据有限。为了独立于传统的心血管危险因素评估瘦素浓度与心肌梗死(MI)和中风病史之间的关系，我们分析了6239名受试者(平均年龄47岁；3336名女性)的数据，测量了血清瘦素，并从国家健康和营养检查调查(NHANES)III对心血管危险因素进行了全面评估。采用Logistic回归分析瘦素浓度(最高四分位数与最低四分位数)与心肌梗塞病史、中风病史以及MI或中风的复合终点(MI/中风)之间的横向关联。瘦素的性别模型根据年龄、种族、血脂异常、高血压、糖尿病、吸烟和肥胖状况进行了调整。有212名男性患有心肌梗死/中风(5.4%)，154名男性患有心肌梗塞(4.1%)，82名男性患有中风(1.7%)。女性心肌梗塞/卒中135例(2.6%)，心肌梗塞74例(1.5%)，卒中78例(1.4%)。在多因素分析中，男性(优势比[OR]2.41，95%可信区间[CI]1.20~4.93)和女性[优势比(OR)4.26，95%可信区间(CI)1.75~10.73]与MI/卒中显著独立相关；男性(OR 3.16，95%CI 1.40~7.37)和女性(OR 3.96，95%CI 1.29~12.72)合并心梗，女性卒中(OR 3.20，95%CI 1.04~10.54)，男性无(OR 1.37，95%CI 0.38~3.88)。总之，在美国人群中，瘦素浓度的增加与男性和女性的MI/中风显著相关，而不受传统的心血管危险因素和肥胖状况的影响。(C)2007 Elsevier Inc.保留所有权利。
Leptin, an adipose tissue-derived hormone, has been linked to cardiovascular outcomes; however, data are limited in the United States population, especially women. To assess the association between leptin concentrations and history of myocardial infarction (MI) and stroke independently of traditional cardiovascular risk factors, we analyzed data from 6,239 subjects (mean age 47 years; 3,336 women) with measurements of serum leptin and full assessment of cardiovascular risk factors from the National Health and Nutrition Examination Survey (NHANES) III. Logistic regression was used to estimate the cross-sectional association of leptin concentrations (highest quartile versus lowest quartile) and history of MI, stroke, and the composite end point of MI or stroke (MI/stroke). Gender-specific models of leptin were adjusted for age, race, dyslipidemia, hypertension, diabetes, smoking, and obesity status. There were 212 men with MI/stroke (5.4%), 154 with MI (4.1%), and 82 with stroke (1.7%). There were 135 women with MI/stroke (2.6%), 74 with MI (1.5%), and 78 with stroke (1.4%). In multivariate analysis, high leptin level was significantly and independently associated with MI/stroke in men (odds ratio [OR] 2.41, 95% confidence interval [CI] 1.20 to 4.93) and women (OR 4.26,95% CI 1.75 to 10.73); with MI in men (OR 3.16,95% CI 1.40 to 7.37) and women (OR 3.96,95% CI 1.29 to 12.72), and with stroke in women (OR 3.20, 95% CI 1.04 to 10.54) but not in men (OR 1.37, 95% CI 0.38 to 3.88). In conclusion, in the United States population, increased leptin concentrations are significantly associated with MI/stroke in men and women independently of traditional cardiovascular risk factors and obesity status. (C) 2007 Elsevier Inc. All rights reserved.