CONTRAST-ENHANCED 1ST PASS MYOCARDIAL PERFUSION IMAGING - CORRELATION BETWEEN MYOCARDIAL BLOOD-FLOW IN DOGS AT REST AND DURING HYPEREMIA
CONTRAST-ENHANCED 1ST PASS MYOCARDIAL PERFUSION IMAGING - CORRELATION BETWEEN MYOCARDIAL BLOOD-FLOW IN DOGS AT REST AND DURING HYPEREMIA
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DOI：
10.1002/mrm.1910290410
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发表时间：
1993-04-01
影响因子：
3.3
通讯作者：
UGURBIL, K
中科院分区：
文献类型：
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作者：
WILKE, N;SIMM, C;UGURBIL, K
对比增强MR第一次灌注成像在检测和定量低灌注心肌方面的敏感性通过仪器化，闭胸犬模型进行评估，其中通过对左前降支（LAD）施加预定水平的狭窄来诱导分级区域性低灌注。所有测量均在静止和双嘧达莫（DIP）诱导下进行。在给药前立即注射MR造影剂，用MR和放射性标记微球评估心肌灌注。使用具有180度反转预脉冲的Turbo FLASH序列进行超快MR成像。左心房注射Gd-DTPA丸，每次心跳时获取t1加权图像。从LAD和左旋（LCx）灌注床区域的图像中测量的信号强度随时间绘制，生成信号强度随时间曲线（SI时间曲线）。根据指标稀释理论推导出各种流量指标，并对放射性标记微球计算的心肌血流量（MBF）进行了血管舒张和不进行体积校正的比较。MR和MBF数据的相关性表明，灌注图像可以很容易地显示不同的跨壁和局部心肌灌注水平，并通过SI时间曲线准确监测。给药后心肌灌注损伤的检出率明显提高。从SI时间曲线计算的逆平均传输时间与从微球数据得出的绝对MBF呈线性相关。这些结果表明，通过心内注射外源性造影剂，心肌灌注可以通过第一次增强超快MRI进行参数化评估。
The sensitivity of contrast-enhanced MR first pass perfusion imaging in detection and quantification of hypoperfused myocardium was evaluated using an instrumented, closed-chest dog model where graded regional hypoperfusion was induced by applying predetermined levels of stenosis to the left anterior descending artery (LAD). All measurements were performed at rest and under stress induced by dipyridamole (DIP). Myocardial perfusion was assessed both with MR and radiolabeled microspheres injected immediately before the administration of the MR contrast agent. Ultrafast MR imaging was performed using a Turbo FLASH sequence with a 180-degrees inversion prepulse. A Gd-DTPA bolus was injected into the left atrium and T1-weighted images were acquired with every heart beat. Signal intensity measured from the images in regions of the LAD and left circumflex (LCx) perfusion beds was plotted against time to generate signal intensity versus time curves (SI time curve). Various flow indices were derived according to the indicator dilution theory, and compared with and without volume correction due to vasodilation to the myocardial blood flow (MBF) calculated from radiolabeled microspheres. Correlation of the MR and MBF data demonstrated that different transmural and regional myocardial perfusion levels can be easily visualized in the perfusion images and accurately monitored by the SI time curves. Detection of the impairment of myocardial perfusion improved significantly after administration of DIP. The inverse mean transit time calculated from the SI time curve was found to yield a linear correlation to absolute MBF derived from the microsphere data. These results suggest that with intracardiac injections of exogenous contrast agent, myocardial perfusion can be assessed parametrically with first pass contrast enhanced ultrafast MRI.