Correlation between tubulointerstitial nephropathy and glomerular lesions induced by adriamycin.
Correlation between tubulointerstitial nephropathy and glomerular lesions induced by adriamycin.
复制标题
肾小管间质性肾病与阿霉素所致肾小球病变的相关性。
作者：
A. Güezmes;F. Fernández;F. Garijo;F. Val
本文描述了一个形态计量学研究的演变，肾小管间质性肾病阿霉素诱导局灶性和节段性肾小球硬化症在32周龄以上的Wistar大鼠。最早的变化位于肾小球。在研究的第10周，出现了肾小管间质性肾病，尽管第2周后间质空间增加，但这种增加仅在第10周后才具有统计学意义。蛋白尿与间质间隙相关性最高，然而，间质间隙与受累肾小球总数相关性指数最高，与Bowman囊粘连和增厚程度较低。
This paper describes a morphometric study of the evolution of tubulointerstitial nephropathy in adriamycin-induced focal and segmental glomerulosclerosis in Wistar rats over 32 weeks old. The earliest changes were located in the glomeruli. In the 10 week of the study, tubulointerstitial nephropathy appeared and, although the interstitial space increased after the 2nd week, this increase only became statistically significant after the 10 week. Proteinuria showed the highest correlation with the interstitial space, however, the interstitial space showed the highest correlation indices with the total number of glomeruli affected and to a lesser extent with adhesions to and thickening of Bowman's capsule.