Janus Ag/Ag2S beads as efficient photothermal agents for the eradication of inflammation and artery stenosis
Janus Ag/Ag2S beads as efficient photothermal agents for the eradication of inflammation and artery stenosis
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Janus Ag/Ag2S 珠作为有效的光热剂，可消除炎症和动脉狭窄
DOI：
10.1039/c9nr04804a
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发表时间：
2019
期刊：
影响因子：
6.7
通讯作者：
Hu Junqing
中科院分区：
文献类型：
--
作者：
Peng Xuan;Liu Junchao;Li Bo;Guan Guoqiang;Zhang Wenlong;Huang Xiaojuan;Chen Yusheng;Zou Rujia;Lu Xinwu;Hu Junqing
Janus异质结构材料作为光热剂，具有增强的光转换能力，有望通过巨噬细胞热疗动脉炎症，巨噬细胞是动脉炎症反应的原始部分，可以恶化为动脉粥样硬化甚至破裂血管。本文提出了一种具有亲水性配体的Janus Ag/Ag2S微球的合成路线，该路线对浓度、时间和表面功能化具有精确的控制。这些Ag/Ag2S异源二聚体的直径约为90 nm，其中Ag纳米晶的直径约为25 nm，光热转换效率高达50.0%，具有相对较低的生物毒性和良好的生物相容性。重要的是，制备的Janus Ag/Ag2S微珠具有较高的生物安全性，可被巨噬细胞有效吞噬，并具有通过该材料优异的光热效应将巨噬细胞从动脉炎症的原始状态中清除的显著益处，而不会对体内动脉和主要器官造成进一步的损伤。这项研究进一步促进了血管炎症治疗的发展，通过在内膜环境中巨噬细胞的光热融化。
Janus heterostructural materials as photothermal agents with enhanced optical conversion capability are promising for artery inflammation treatment by the hyperthermia of macrophages, a primordial part in the artery inflammation response that can deteriorate into atherosclerosis and even break the vessels. Herein, a synthesis route of Janus Ag/Ag2S beads with hydrophilic ligands has been developed with a precise control over concentration, time and surface functionalization. These Ag/Ag2S heterodimers show desirable sizes of around 90 nm in diameter, in which Ag nanocrystals have a diameter of around 25 nm, and they exhibit a photothermal conversion efficiency of up to 50.0% as well as relatively low biotoxicity and good biocompatibility. Importantly, the as-prepared Janus Ag/Ag2S beads with a high biological safety can be effectively swallowed by macrophages and have a remarkable benefit of eliminating these cells from the original state of artery inflammation through the excellent photothermal effect of this material, without causing any further damage to the arteries and major organs in vivo. This study further promotes the development of treatment for vascular inflammation by the photothermal melting of macrophage cells in intima environments.