Dual Spinal Lesion Paradigm in the Cat: Evolution of the Kinematic Locomotor Pattern
Dual Spinal Lesion Paradigm in the Cat: Evolution of the Kinematic Locomotor Pattern
复制标题
DOI：
10.1152/jn.00255.2010
复制
发表时间：
2010-08-01
影响因子：
2.5
通讯作者：
Rossignol, Serge
中科院分区：
文献类型：
--
作者：
Barriere, Gregory;Frigon, Alain;Rossignol, Serge
巴里埃G，Frigon A，Leblond H，Provencher J，Rossignol S.猫的双脊髓损伤范例：运动运动模式的演变。J Neurophysiol 104：1119-1133，2010.首次发表于2010年6月23日; doi：10.1152/jn.00255.2010。不完全脊髓损伤后自主四足运动的恢复可能涉及不同水平的CNS，包括脊髓运动回路。后一个结论是使用双脊柱病变范例得出的，其中在几周后，通过完全脊柱横断（即，spinalization）。在这种双脊髓损伤范例中，猫可以在脊髓化后1天表达后肢行走，这一过程通常需要数周，表明腰骶脊髓内的运动回路在部分损伤后已经改变。在这里，我们详细介绍了整个双脊髓损伤范例的五只猫的运动模式的演变，以进一步了解假定的神经生理机制参与运动恢复后的部分脊髓损伤。所有的猫恢复自愿四足运动与跑步机训练（3-5天/周）超过几个星期。部分病变后，运动模式的特点是几个左/右不对称的各种运动学参数，如同侧和同源interlimb耦合，周期持续时间，摆动/站立持续时间。当没有观察到进一步的运动改善时，将猫脊髓化。脊髓化后，后肢运动模式迅速重现，但左/右不对称的摆动/站立持续时间后观察到的部分病变可能消失或逆转。它的结论是，部分脊髓损伤后，后肢运动模式积极维护脊髓和脊髓上水平之间的新的动态相互作用，但也内在的变化脊髓。
Barriere G, Frigon A, Leblond H, Provencher J, Rossignol S. Dual spinal lesion paradigm in the cat: Evolution of the kinematic locomotor pattern. J Neurophysiol 104: 1119-1133, 2010. First published June 23, 2010; doi:10.1152/jn.00255.2010. The recovery of voluntary quadrupedal locomotion after an incomplete spinal cord injury can involve different levels of the CNS, including the spinal locomotor circuitry. The latter conclusion was reached using a dual spinal lesion paradigm in which a low thoracic partial spinal lesion is followed, several weeks later, by a complete spinal transection (i.e., spinalization). In this dual spinal lesion paradigm, cats can express hindlimb walking 1 day after spinalization, a process that normally takes several weeks, suggesting that the locomotor circuitry within the lumbosacral spinal cord had been modified after the partial lesion. Here we detail the evolution of the kinematic locomotor pattern throughout the dual spinal lesion paradigm in five cats to gain further insight into putative neurophysiological mechanisms involved in locomotor recovery after a partial spinal lesion. All cats recovered voluntary quadrupedal locomotion with treadmill training (3-5 days/wk) over several weeks. After the partial lesion, the locomotor pattern was characterized by several left/right asymmetries in various kinematic parameters, such as homolateral and homologous interlimb coupling, cycle duration, and swing/stance durations. When no further locomotor improvement was observed, cats were spinalized. After spinalization, the hindlimb locomotor pattern rapidly reappeared, but left/right asymmetries in swing/stance durations observed after the partial lesion could disappear or reverse. It is concluded that, after a partial spinal lesion, the hindlimb locomotor pattern was actively maintained by new dynamic interactions between spinal and supraspinal levels but also by intrinsic changes within the spinal cord.