Rate of progression in open-angle glaucoma estimated from cross-sectional prevalence of visual field damage
Rate of progression in open-angle glaucoma estimated from cross-sectional prevalence of visual field damage
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DOI：
10.1016/s0002-9394(14)72062-8
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发表时间：
1996-09-01
影响因子：
4.2
通讯作者：
Sommer, A
中科院分区：
文献类型：
--
作者：
Quigley, HA;Tielsch, JM;Sommer, A
目得：估计开角型青光眼患者的视野丧失率。方法：对来自巴尔的摩眼科调查的151名开角型青光眼患者的Goldmann视野检查法获得的视野数据进行9级严重程度分级。这些人中约有一半以前曾被诊断为青光眼，目前正在接受治疗。使用回归分析，将他们的分数与其他特征进行比较，包括年龄，垂直杯/盘比，治疗状态，性别，种族和眼内压，这些数据用于估计青光眼进行性视野丢失和失明的平均率。在112名黑人受试者中，视野损害的严重程度与年龄显著相关（P <0.02）、青光眼治疗史（P <0.04）和眼压（P <0.0001）。利用年龄与损害之间的关系，eve估计黑色青光眼受试者的恶化率为每十年两个分级水平，这与以前的报道一致，对于39名白色受试者，纳入年龄改善了损害评分与其他变量之间的模型关系。白人个体损伤率的最佳估计值与黑人相似。然而，在白人的年龄和损害的统计学关联是不太强，比黑人，可能是因为较少的白色科目在sample.CONCLUSIONS：虽然青光眼是一种常见的原因视力残疾，罕见的进行性视野丧失是不足以导致双侧失明的大多数受影响。青光眼治疗的积极性应与视野丧失率相关，强调确认进展延缓。
PURPOSE: To estimate the rate of visual field loss in persons with open angle glaucoma.METHODS: The visual field data obtained by Goldmann perimetry from 151 persons with open-angle glaucoma from the Baltimore Eye Survey were graded on a nine-level severity scale. Approximately one half of these persons had previously diagnosed glaucoma and were being treated. Using regression analysis, their scores were compared to other features, including age, vertical cup/disk ratio, treatment status, gender, race, and intraocular pressure, These data were used to estimate the average rate of progressive field loss and blindness in glaucoma.RESULTS: Among 112 black subjects, the severity of visual field damage was significantly associated with age (P < .02), history of glaucoma treatment (P < .04), and intraocular pressure (P < .0001). Using the relationship between age and damage, eve estimated that the rate of deterioration of black glaucoma subjects was two grading levels per decade, which is consistent with previous reports, For 39 white subjects, the inclusion of age improved the model relationship between damage score and other variables. The best estimate of individual damage rate for whites was similar to that in blacks. However, the statistical association of age and damage in whites was less strong than in blacks, possibly because of fewer white subjects in the sample.CONCLUSIONS: While glaucoma is a frequent cause of visual disability, rare of progressive visual field loss is not sufficient to lead to bilateral blindness in the majority of those affected. Aggressiveness of glaucoma therapy should be related to the rate of visual field loss stressing confirmation of held progression.