Control of Apoptosis in Treatment and Biology of Pancreatic Cancer.
Control of Apoptosis in Treatment and Biology of Pancreatic Cancer.
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DOI：
10.1002/jcb.25284
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发表时间：
2016-02
影响因子：
4
通讯作者：
Saluja A
中科院分区：
文献类型：
--
作者：
Modi S;Kir D;Banerjee S;Saluja A
据估计，胰腺癌是2014年美国第12大最常见的癌症，但这种恶性肿瘤是美国癌症相关死亡的第四大原因。发现晚和对治疗的抵抗是其预后不佳的主要原因。细胞凋亡是一种主动安排的细胞死亡机制，用于维持组织的平衡。癌症是由正常细胞通过一种或多种机制发生重大变化而发展起来的，导致DNA损伤和突变，这在正常细胞中会诱发这种程序性细胞死亡途径。因此，逃避细胞凋亡是癌细胞的特征之一。众所周知，PDAC对细胞凋亡具有抗性，因此解释了其侵袭性和对常规治疗方式的抗性。目前的综述重点是了解胰腺癌中可能影响该疾病细胞凋亡的不同内在和外在途径。
Pancreatic cancer is estimated to be the 12th most common cancer in the United States in 2014 and yet this malignancy is the fourth leading cause of cancer-related death in the United States. Late detection and resistance to therapy are the major causes for its dismal prognosis. Apoptosis is an actively orchestrated cell death mechanism that serves to maintain tissue homoeostasis. Cancer develops from normal cells by accruing significant changes through one or more mechanisms, leading to DNA damage and mutations, which in a normal cell would induce this programmed cell death pathway. As a result, evasion of apoptosis is one of the hallmarks of cancer cells. PDAC is notoriously resistant to apoptosis, thereby explaining its aggressive nature and resistance to conventional treatment modalities. The current review is focus on understanding different intrinsic and extrinsic pathways in pancreatic cancer that may affect apoptosis in this disease.
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影响因子：
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