Lactobacillus kunkeei strains decreased the infection by honey bee pathogens Paenibacillus larvae and Nosema ceranae
Lactobacillus kunkeei strains decreased the infection by honey bee pathogens Paenibacillus larvae and Nosema ceranae
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DOI：
10.3920/bm2017.0075
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发表时间：
2018-01-01
影响因子：
5.4
通讯作者：
Antunez, K.
中科院分区：
文献类型：
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作者：
Arredondo, D.;Castelli, L.;Antunez, K.
由于它们的社会行为，蜜蜂可以被广泛的病原体感染，包括微孢子虫微孢子虫和细菌类芽孢杆菌幼虫。使用益生菌作为食品添加剂来控制或预防传染病是一种广泛使用的改善人类和动物健康的方法。在这项工作中，我们产生了从蜜蜂肠道微生物群落中分离的四种孔氏乳杆菌菌株的混合物，并评估了其对幼虫和成年蜜蜂的潜在有益作用。其在受控实验室模型中的施用对幼虫和蜜蜂是安全的;它不影响免疫相关基因的表达，并且能够降低与幼虫P.幼虫感染相关的幼虫死亡率和N.成年蜜蜂的孢子。这些有希望的结果表明，这种有益微生物的混合物可能是改善蜜蜂健康的有吸引力的策略。正在进行实地研究，以评估其在自然感染群体中的效果。
Due to their social behaviour, honey bees can be infected by a wide range of pathogens including the microsporidia Nosema ceranae and the bacteria Paenibacillus larvae. The use of probiotics as food additives for the control or prevention of infectious diseases is a widely used approach to improve human and animal health. In this work, we generated a mixture of four Lactobacillus kunkeei strains isolated from the gut microbial community of bees, and evaluated its potential beneficial effect on larvae and adult bees. Its administration in controlled laboratory models was safe for larvae and bees; it did not affect the expression of immune-related genes and it was able to decrease the mortality associated to P. larvae infection in larvae and the counts of N. ceranae spores from adult honey bees. These promising results suggest that this beneficial microorganism's mixture may be an attractive strategy to improve bee health. Field studies are being carried out to evaluate its effect in naturally infected colonies.