A prospective study of alcohol consumption and cataract extraction among US women
A prospective study of alcohol consumption and cataract extraction among US women
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DOI：
10.1016/s1047-2797(00)00054-5
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发表时间：
2000-08-01
影响因子：
5.6
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
--
作者：
Chasan-Taber, L;Willet, WC;Hankinson, SE
目的：在一些（但并非所有）分析研究中，饮酒与白内障的发病机制有关。迄今为止，尚未对女性饮酒与白内障之间的关系进行前瞻性分析。方法：我们在女性注册护士的前瞻性队列中研究了饮酒与白内障摘除术之间的关联。 1980年，有50,461名女性被纳入其中，当她们年满45岁时，又增加了其他女性，总共有77,466名女性。在为期 12 年的随访期间，通过两年一次的问卷调查确定了有关饮酒量和老年性白内障摘除术发生率的信息。结果：我们在 761,036 人年的随访中观察到了 1468 例白内障摘除术病例。与不饮酒者相比，饮酒者患白内障的风险并未增加，甚至每天饮酒量达到 25 克或更多（2 杯或更多饮酒）（相对风险 [RR] = 1.10，95% 置信区间 [CI] = 0.90、1.35）。在控制了吸烟、体重指数和糖尿病等白内障危险因素后，结果保持不变。当仅检查特定白内障亚型的风险时，最高消费类别的患者核性白内障的多变量相对风险为 1.10 (95% CI = 0.74, 1.62)，仅后囊下白内障的多变量相对风险为 1.50 (95% CI = 0.98, 2.30)。 结论：这些前瞻性数据表明，老年性白内障总体风险并未显着增加。酒精引起的白内障 摄入量。饮酒会导致后囊下型混浊需要拔除的风险适度增加，这一可能性值得进一步探讨。安流行病学 2000；10：347-353。 (C) 2000 Elsevier Science Inc. 保留所有权利。
PURPOSE: Alcohol consumption has been implicated in the pathogenesis of cataract in some, but not all analytic studies. To date, no prospective analysis of the relationship between alcohol consumption and cataract has been conducted in women.METHODS: We examined the association between alcohol consumption and cataract extraction in a prospective cohort of female registered nurses. In 1980, 50,461 women were included and others were added as they became 45 years of age for a total of 77,466 women. Information on alcohol consumption and incidence of senile cataract extraction was ascertained during 12 years of follow-up with biennial questionnaires.RESULTS: We observed 1468 cases of cataract extraction in 761,036 person-years of follow-up. Compared to nondrinkers, those consuming alcohol were not at increased risk of cataract, even up to 25 grams or more per day (2 or more drinks) (relative risk [RR] = 1.10, 95% confidence interval [CI] = 0.90, 1.35). Results remained unchanged after controlling for cataract risk factors including cigarette smoking, body mass index, and diabetes. When risk was examined for specific cataract subtypes only, those in the highest category of consumption had a multivariate relative risk of 1.10 (95% CI = 0.74, 1.62) for nuclear cataracts and 1.50 (95% CI = 0.98, 2.30) for posterior subcapsular cataracts only.CONCLUSIONS: These prospective data suggest that there is no substantial overall increased risk of senile cataract due to alcohol intake. The possibility that alcohol consumption leads to a modest increased risk of posterior subcapsular type opacities requiring extraction merits further exploration. Ann Epidemiol 2000;10:347-353. (C) 2000 Elsevier Science Inc. All rights reserved.