GAMMA-PROBE-GUIDED LYMPH-NODE LOCALIZATION IN MALIGNANT-MELANOMA
GAMMA-PROBE-GUIDED LYMPH-NODE LOCALIZATION IN MALIGNANT-MELANOMA
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DOI：
10.1016/s0960-7404(06)80006-x
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发表时间：
1993-10-01
影响因子：
2.3
通讯作者：
KRAG, DN
中科院分区：
文献类型：
--
作者：
ALEX, JC;WEAVER, DL;KRAG, DN
已使用术中活体染料标测成功定位初始引流淋巴结（前哨淋巴结），据报道可预测临床1期黑色素瘤的区域淋巴结转移[1]。在动物模型中，我们先前建立了锝-99硫胶体标记前哨淋巴结的γ探针引导定位技术[2]，并发现其灵敏度与活体染料标测相当。我们现在报告我们的初步经验，使用伽玛探头引导定位，以确定，然后手术切除第一引流淋巴结（S）在10例恶性黑色素瘤患者。使用荧光造影术来确认定位。我们的结论是，这项技术：（a）可靠地定位前哨淋巴结引流的网站的原发性黑色素瘤，（B）允许淋巴床检查术中验证完整的前哨淋巴结活检，（c）是相对简单，可以在局部麻醉下进行。
The initial draining lymph node (sentinel node) has been successfully localized using intraoperative vital dye mapping and reportedly is predictive of regional nodal metastases in Clinical Stage 1 melanoma [1]. In an animal model, we previously established the technique of gamma-probe-guided localization of the technetium-99 sulfur colloid labelled sentinel node [2] and found its sensitivity equal to vital dye mapping. We now report our initial experience using gamma-probe-guided localization to identify and then surgically remove the first draining lymph node(s) in 10 malignant melanoma patients. Lymphoscintigraphy was used to confirm localization. We conclude that this technique: (a) reliably localizes the sentinel node draining the site of a primary melanoma, (b) allows the lymphatic bed to be checked intraoperatively verifying complete sentinel node biopsy, and (c) is relatively simple and can be performed under local anaesthesia.