Prevalence of penile human papillomavirus DNA in husbands of women with and without cervical neoplasia: A study in Spain and Colombia
Prevalence of penile human papillomavirus DNA in husbands of women with and without cervical neoplasia: A study in Spain and Colombia
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DOI：
10.1086/514052
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发表时间：
1997-08-01
影响因子：
6.4
通讯作者：
Shah, KV
中科院分区：
文献类型：
--
作者：
Castellsague, X;Ghaffari, A;Shah, KV
为了研究男性在宫颈癌中的作用，816名女性的丈夫参加了4项宫颈癌病例对照研究，研究对象是高血压人群。（哥伦比亚）和宫颈癌低风险（西班牙）进行了采访，获得了阴茎脱落细胞，并通过聚合酶链反应分析了人乳头瘤病毒（HPV）DNA的存在，宫颈肿瘤妇女的丈夫阴茎HPV DNA患病率高于对照组的丈夫，哥伦比亚对照组的丈夫阴茎HPV DNA患病率是西班牙相应丈夫的5倍，在西班牙，阴茎HPV DNA患病率与所有性行为相关变量之间存在较强的剂量反应关系，但在哥伦比亚，性滥交是阴茎HPV感染最重要的危险因素。西班牙和哥伦比亚男性人群中HPV DNA患病率的差异与宫颈癌发病率的8倍差异一致。
To investigate the role of men in cervical cancer, 816 husbands of women enrolled in four case-control studies of cervical neoplasia in populations at high (Colombia) and low (Spain) risk for cervical cancer were interviewed, Exfoliated cells from the penis were obtained and analyzed by polymerase chain reaction for the presence of human papillomavirus (HPV) DNA, Penile HPV DNA prevalences were higher in husbands of women with cervical neoplasia than in husbands of controls, Husbands of controls in Colombia had a 5-fold higher penile HPV DNA prevalence than the corresponding husbands in Spain, Strong dose-response relationships were found between penile HPV DNA prevalence and all sexual behavior-related variables in Spain but not in Colombia, Sexual promiscuity is the most important risk factor for penile HPV infections. Differences in HPV DNA prevalence in the male populations of Spain and Colombia are consistent with their 8-fold difference in cervical cancer incidences.