JMJD2C triggers the growth of multiple myeloma cells via activation of β‑catenin.
JMJD2C triggers the growth of multiple myeloma cells via activation of β‑catenin.
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JMJD2C通过激活β-蛋白触发了多发性骨髓瘤细胞的生长。
DOI：
10.3892/or.2021.7934
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发表时间：
2021-03
期刊：
影响因子：
4.2
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Lv M;Liu Q
新的证据表明，组蛋白修饰及其相关调控因子参与了多发性骨髓瘤（MM）细胞的进展。在本研究中，在MM组织和健康对照中检测了Jumonji C结构域包含2（JMJD 2）的表达。进一步研究了JMJD 2C在MM进展中的作用。结果显示，与健康对照相比，MM组织中JMJD 2C的表达增加，但JMJD 2A或JMJD 2B的表达没有增加。JMJD 2C的过表达显著增加MM细胞的体外生长。β-连环蛋白信号通路的抑制剂显著减弱了JM JD 2C诱导的MM细胞生长。机制分析表明，JMJD 2C能促进MM细胞中β-catenin的转录，这可能与JMJD 2C能直接与β-catenin的启动子结合有关。此外，JMJD 2C通过GSK 3 β依赖性方式激活MM细胞中的β-catenin，这通过以下结果证明：GSK 3 β的过表达减弱了JMJD 2C诱导的β-catenin磷酸化的降低。总体而言，本研究的结果表明，JMJD 2C通过激活β-catenin通路促进MM的恶性化。这些结果表明，JMJD 2C可能是MM治疗的潜在靶点。
Emerging evidence has indicated that histone modification and its related regulators are involved in the progression of multiple myeloma (MM) cells. In the present study, the expression of Jumonji C domain-containing 2 (JMJD2) was examined in both MM tissues and healthy controls. The roles of JMJD2C in the progression of MM were further investigated. The results revealed that the expression of JMJD2C, but not that of JMJD2A or JMJD2B, was increased in MM tissues compared with the healthy controls. The overexpression of JMJD2C significantly increased the in vitro growth of MM cells. The inhibitor of the β-catenin signaling pathway significantly attenuated the JMJD2C-induced growth of MM cells. Mechanistical analyses indicated that JMJD2C increased the transcription of β-catenin in MM cells, which may be due to the fact that JMJD2C can directly bind with the promoter of β-catenin. Furthermore, JMJD2C activated β-catenin in MM cells via a GSK3β-dependent manner, which was evidenced by the results demonstrating that the overexpression of GSK3β attenuated the JMJD2C-induced decrease in the phosphorylation of β-catenin. On the whole, the findings of the present study demonstrated that JMJD2C promotes the malignancy of MM via the activation of the β-catenin pathway. These results suggested that JMJD2C may be a potential target for MM treatment.
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影响因子：
5.7
作者：
Hideshima T;Richardson PG;Anderson KC
通讯作者：
Anderson KC
影响因子：
5.7
作者：
Hui, Rosaline C-Y.;Francis, Richard E.;Lam, Eric W-F.
通讯作者：
Lam, Eric W-F.
影响因子：
10.5
作者：
Agger K;Miyagi S;Pedersen MT;Kooistra SM;Johansen JV;Helin K
通讯作者：
Helin K
DOI：
10.1073/pnas.1403565111
发表时间：
2014-06-24
影响因子：
11.1
作者：
Ayrapetov, Marina K.;Gursoy-Yuzugullu, Ozge;Price, Brendan D.
通讯作者：
Price, Brendan D.
影响因子：
8
作者：
Liu, G.;Bollig-Fischer, A.;Kreike, B.;van de Vijver, M. J.;Abrams, J.;Ethier, S. P.;Yang, Z-Q
通讯作者：
Yang, Z-Q