INVERTED REPEAT NUCLEOTIDE-SEQUENCES IN THE GENOMES OF MAREK DISEASE VIRUS AND THE HERPESVIRUS OF THE TURKEY
INVERTED REPEAT NUCLEOTIDE-SEQUENCES IN THE GENOMES OF MAREK DISEASE VIRUS AND THE HERPESVIRUS OF THE TURKEY
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DOI：
10.1073/pnas.79.2.555
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
SHELDRICK, P
中科院分区：
文献类型：
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作者：
CEBRIAN, J;KASCHKADIERICH, C;SHELDRICK, P
本文用电镜技术对两种疱疹病毒DNA进行了研究，即致瘤性马立克氏病病毒和血清学相关的火鸡疱疹病毒。基于在两种病毒的单链DNA中观察到的折回分子，推导出它们基因组中的总体核苷酸序列排列的结构。虽然分子量不同，但马立克氏病病毒和火鸡疱疹病毒的基因组都是根据相同的计划构建的，2个独特的核苷酸序列区域各自被反向重复序列包围。这些病毒的基因组结构非常类似于单纯疱疹病毒，而不是生物学上更相似的爱泼斯坦-巴尔病毒，松鼠猴疱疹病毒和疱疹病毒。
The DNA of 2 herpesviruses, the oncogenic Marek disease virus and the serologically related herpesvirus of the turkey, were studied by EM. On the basis of fold-back molecules observed in single-stranded DNA from both viruses, structures were derived for the overall nucleotide sequence arrangement in their genomes. Although differing in MW, the genomes of Marek disease virus and turkey herpesvirus are both constructed according to the same plan, 2 regions of unique nucleotide sequence each enclosed by inverted repeat sequences. The genome structure of these viruses closely resembles that of herpes simplex virus rather than the biologically more similar Epstein-Barr virus, Herpesvirus saimiri and Herpesvirus ateles.