Central effects of quinpirole on blood pressure of spontaneously hypertensive rats.
Central effects of quinpirole on blood pressure of spontaneously hypertensive rats.
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喹吡罗对自发性高血压大鼠血压的中枢作用。
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发表时间：
1992
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影响因子：
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通讯作者：
M. van den Buuse
中科院分区：
文献类型：
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作者：
M. van den Buuse
静脉注射。给予多巴胺D-2受体激动剂奎比罗可引起自发性高血压大鼠(SHR)血压迅速升高。心率变化不大。0.03~0.3 mg/kg的剂量对SHR和正常血压的Wistar-京都大鼠(WKY)的升压反应相似，但当剂量为1 mg/kg时，SHR的血压升高幅度大于WKY。相反，尽管两个菌株在给药0.01-0.05 mg/kg喹比罗后都表现出运动活性降低，但只有WKY的活性在给药0.25-1.25 mg/kg时被增强。静脉注射。注射多巴胺激动剂阿朴吗啡、N-丙基去甲吗啡和(R)-(+)-3-(3-hydroxyphenyl)-N-propylpiperidine，，但不注射突触前D-2激动剂(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶，引起的升压反应与给药后相似。外周D-2拮抗剂多潘立酮可增强奎比罗的升压作用，中枢作用的多巴胺拮抗剂氟哌啶醇或舒必利可阻断其升压作用。在用百日咳毒素进行中央处理的SHR中，奎比罗引起的血压升高明显小于对照SHR。中枢注射6-羟基多巴胺对奎比罗的升压作用无影响。静脉注射后30分钟。注射奎比罗后，再注射一次奎比罗并未显著改变血压。延长随后两次注射奎比罗的间隔时间显示，这种脱敏反应缓慢逆转，但只有在24小时后，对奎比罗的升压反应才完全恢复。
The i.v. administration of the dopamine D-2 receptor agonist quinpirole induced a rapid increase in blood pressure in spontaneously hypertensive rats (SHR). Heart rate showed little change. The pressor response to quinpirole was similar in SHR and normotensive Wistar-Kyoto rats (WKY) at doses of 0.03 to 0.3 mg/kg but, at 1 mg/kg, quinpirole induced a greater increase in blood pressure in SHR than in WKY. In contrast, although both strains showed a decreased locomotor activity after administration of 0.01 to 0.05 mg/kg of quinpirole, only in WKY was activity enhanced by 0.25 to 1.25 mg/kg of quinpirole. The i.v. administration of the dopamine agonists apomorphine, N-propylnorapomorphine and (R)-(+)-3-(3-hydroxyphenyl)-N-propylpiperidine, but not the putative presynaptic D-2 agonist (S)-(-)-3-(3-hydroxyphenyl)-N- propylpiperidine, induced pressor responses in SHR comparable to those after quinpirole administration. The pressor effect of quinpirole was enhanced by pretreatment with the peripheral D-2 antagonist domperidone, but blocked by the centrally acting dopamine antagonists haloperidol or sulpiride. In SHR, which were pretreated centrally with pertussis toxin, quinpirole induced a significantly smaller increase in blood pressure than in control SHR. Pretreatment centrally with 6-hydroxydopamine had no effect on the pressor action of quinpirole in SHR. Thirty minutes after i.v. administration of quinpirole, an additional injection of quinpirole did not significantly change blood pressure. Increasing the interval between two subsequent injections of quinpirole showed that this desensitization slowly reversed, but only after 24 hr had the pressor response to quinpirole fully recovered.(ABSTRACT TRUNCATED AT 250 WORDS)